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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Ultrasound 2017 ; 45 (3): 168-170 Nephropedia Template TP
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A multidisciplinary approach to prenatal treatment of congenital long QT syndrome #MMPMID27492745
J Clin Ultrasound 2017[Mar]; 45 (3): 168-170 PMID27492745show ga
A 27-week fetus evaluated for bradycardia and hydrops was found to have anti-SSA-negative 2 degrees atrioventricular block and ventricular tachycardia. A presumptive diagnosis of fetal long QT syndrome was made. Transplacental pharmacotherapy with intravenous magnesium and lidocaine restored sinus rhythm. At 30 6/7 weeks, the infant was delivered due to premature labor. Despite postnatal treatment with mexiletine and propranolol, she developed torsades de pointes. Ultimately, a de novo KCNH2 G628S mutation was diagnosed. She received an implantable cardiac defibrillator at 5 months of age. Early diagnosis and a multidisciplinary approach allowed successful in utero treatment and anticipatory postnatal management. (c) 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:168-170, 2017.