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10.1097/MPA.0000000000000685 http://scihub22266oqcxt.onion/10.1097/MPA.0000000000000685 27464700!ä!27464700 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pancreas 2017 ; 46 (1): 97-101 Nephropedia Template TP {{tp|p=27464700|t=2017. Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic beta-Cells |pdf=|usr=}}{{27464700}} gab.com Text Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic beta-Cells JO: Pancreas http://www.kidney.de/pget.php?&tw=1&pmid=27464700 #FOAvip OBJECTIVE: Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic beta-cells. The expression and the relative abundance of different TRP channels in the human beta-cells are unknown. The objective of this study was to examine the expression of the TRP channels and their relative abundance in the human beta-cell. METHODS: RNA sequencing data obtained from human islets, fluorescence-activated cell sorting-purified human beta-cell and human pancreatic acinar cells were analyzed. Gene counts and fragments per kilobase per million mapped reads were obtained. RESULTS: Among the TRPC family only the TRPC1 was expressed in the human beta-cell. TRPV1 channels were not expressed in the human beta-cells. Among the TRPM family, TRPM4, TRPM7, TRPM2, and TRPM3 were expressed in the human beta-cell. Of the remaining TRP channels, TRPP2, TRPML1, and TRPML3 were expressed in these cells. CONCLUSIONS: By analyzing the RNA sequencing data, we have detected for the first time the TRP channels that are expressed in the purified human beta-cells, in comparison to the other relevant pancreatic cell types. Our study provides an opportunity to focus on these TRP channels for a better understanding of the electrophysiology and stimulus-secretion coupling in these cells. Twit Text FOAVip Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic beta-Cells ????Pancreas http://www.kidney.de/pget.php?&tw=1&pmid=27464700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27464700 #FOAvip English Wikipedia <ref>{{Cite pmid|27464700}}</ref> Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic beta-Cells #MMPMID27464700 Marabita F; Islam MS Pancreas 2017[Jan]; 46 (1): 97-101 PMID27464700show ga OBJECTIVE: Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic beta-cells. The expression and the relative abundance of different TRP channels in the human beta-cells are unknown. The objective of this study was to examine the expression of the TRP channels and their relative abundance in the human beta-cell. METHODS: RNA sequencing data obtained from human islets, fluorescence-activated cell sorting-purified human beta-cell and human pancreatic acinar cells were analyzed. Gene counts and fragments per kilobase per million mapped reads were obtained. RESULTS: Among the TRPC family only the TRPC1 was expressed in the human beta-cell. TRPV1 channels were not expressed in the human beta-cells. Among the TRPM family, TRPM4, TRPM7, TRPM2, and TRPM3 were expressed in the human beta-cell. Of the remaining TRP channels, TRPP2, TRPML1, and TRPML3 were expressed in these cells. CONCLUSIONS: By analyzing the RNA sequencing data, we have detected for the first time the TRP channels that are expressed in the purified human beta-cells, in comparison to the other relevant pancreatic cell types. Our study provides an opportunity to focus on these TRP channels for a better understanding of the electrophysiology and stimulus-secretion coupling in these cells. |*Gene Expression Profiling[MESH] |Cluster Analysis[MESH] |Humans[MESH] |Insulin-Secreting Cells/*metabolism[MESH] |Protein Isoforms/genetics[MESH] |TRPC Cation Channels/genetics[MESH] |TRPM Cation Channels/genetics[MESH] |TRPP Cation Channels/genetics[MESH]Expression of Transient Receptor Potential Channels in the Purified Hu(epmc).pdf DeepDyve Pubget Overpricing