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http://scihub22266oqcxt.onion/ 27440992!4942261!27440992     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Vis 2016 ; 22 (ä): 734-47 Nephropedia Template TP {{tp|p=27440992|t=2016. Mechanism of the anticataract effect of liposomal MgT in galactose-fed rats |pdf=|usr=}}{{27440992}} gab.com Text Mechanism of the anticataract effect of liposomal MgT in galactose-fed rats JO: Mol Vis http://www.kidney.de/pget.php?&tw=1&pmid=27440992 #FOAvip PURPOSE: Increased lenticular oxidative stress and altered calcium/magnesium (Ca/Mg) homeostasis underlie cataractogenesis. We developed a liposomal formulation of magnesium taurate (MgT) and studied its effects on Ca/Mg homeostasis and lenticular oxidative and nitrosative stress in galactose-fed rats. METHODS: The galactose-fed rats were topically treated with liposomal MgT (LMgT), liposomal taurine (LTau), or corresponding vehicles twice daily for 28 days with weekly anterior segment imaging. At the end of the experimental period, the lenses were removed and subjected to analysis for oxidative and nitrosative stress, Ca and Mg levels, ATP content, Ca(2+)-ATPase, Na(+),K(+)-ATPase, and calpain II activities. RESULTS: The LTau and LMgT groups showed significantly lower opacity index values at all time points compared to the corresponding vehicle groups (p<0.001). However, the opacity index in the LMgT group was lower than that in the LTau group (p<0.05). Significantly reduced oxidative and nitrosative stress was observed in the LTau and LMgT groups. The lens Ca/Mg ratio in LMgT group was decreased by 1.15 times compared to that in the LVh group. Calpain II activity in the LMgT group was decreased by 13% compared to the LVh group. The ATP level and Na(+),K(+)-ATPase and Ca(2+)-ATPase activities were significantly increased in the LMgT group compared to the LVh group (p<0.05). CONCLUSIONS: Topical liposomal MgT delays cataractogenesis in galactose-fed rats by maintaining the lens mineral homeostasis and reducing lenticular oxidative and nitrosative stress. Twit Text FOAVip Mechanism of the anticataract effect of liposomal MgT in galactose-fed rats ????Mol Vis http://www.kidney.de/pget.php?&tw=1&pmid=27440992 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27440992 #FOAvip English Wikipedia <ref>{{Cite pmid|27440992}}</ref> Mechanism of the anticataract effect of liposomal MgT in galactose-fed rats #MMPMID27440992 Iezhitsa I; Agarwal R; Saad SD; Zakaria FK; Agarwal P; Krasilnikova A; Rahman TH; Rozali KN; Spasov A; Ozerov A; Alyautdin R; Ismail NM Mol Vis 2016[]; 22 (ä): 734-47 PMID27440992show ga PURPOSE: Increased lenticular oxidative stress and altered calcium/magnesium (Ca/Mg) homeostasis underlie cataractogenesis. We developed a liposomal formulation of magnesium taurate (MgT) and studied its effects on Ca/Mg homeostasis and lenticular oxidative and nitrosative stress in galactose-fed rats. METHODS: The galactose-fed rats were topically treated with liposomal MgT (LMgT), liposomal taurine (LTau), or corresponding vehicles twice daily for 28 days with weekly anterior segment imaging. At the end of the experimental period, the lenses were removed and subjected to analysis for oxidative and nitrosative stress, Ca and Mg levels, ATP content, Ca(2+)-ATPase, Na(+),K(+)-ATPase, and calpain II activities. RESULTS: The LTau and LMgT groups showed significantly lower opacity index values at all time points compared to the corresponding vehicle groups (p<0.001). However, the opacity index in the LMgT group was lower than that in the LTau group (p<0.05). Significantly reduced oxidative and nitrosative stress was observed in the LTau and LMgT groups. The lens Ca/Mg ratio in LMgT group was decreased by 1.15 times compared to that in the LVh group. Calpain II activity in the LMgT group was decreased by 13% compared to the LVh group. The ATP level and Na(+),K(+)-ATPase and Ca(2+)-ATPase activities were significantly increased in the LMgT group compared to the LVh group (p<0.05). CONCLUSIONS: Topical liposomal MgT delays cataractogenesis in galactose-fed rats by maintaining the lens mineral homeostasis and reducing lenticular oxidative and nitrosative stress. |Animals[MESH] |Calcium/metabolism[MESH] |Calpain/metabolism[MESH] |Cataract/*drug therapy/metabolism/pathology[MESH] |Disease Progression[MESH] |Galactose[MESH] |Homeostasis[MESH] |Lens, Crystalline/drug effects/metabolism[MESH] |Liposomes[MESH] |Magnesium/metabolism[MESH] |Nitrosation[MESH] |Oxidative Stress/drug effects[MESH] |Particle Size[MESH] |Rats, Sprague-Dawley[MESH] |Sodium-Potassium-Exchanging ATPase/metabolism[MESH]Mechanism of the anticataract effect of liposomal MgT in galactose-fed(epmc).pdf DeepDyve Pubget Overpricing