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10.5483/bmbrep.2016.49.9.069 http://scihub22266oqcxt.onion/10.5483/bmbrep.2016.49.9.069 27439603!5227144!27439603     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2016 ; 49 (9): 508-13 Nephropedia Template TP {{tp|p=27439603|t=2016. Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis |pdf=|usr=}}{{27439603}} gab.com Text Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27439603 #FOAvip Hypoxia-inducible factor (HIF)-1alpha is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1alpha regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1alpha inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1alpha and downregulated Akt signaling without affecting the stability of HIF-1alpha protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. [BMB Reports 2016; 49(9): 508-513]. Twit Text FOAVip Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27439603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27439603 #FOAvip English Wikipedia <ref>{{Cite pmid|27439603}}</ref> Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis #MMPMID27439603 Choi SW; Lee KS; Lee JH; Kang HJ; Lee MJ; Kim HY; Park KI; Kim SL; Shin HK; Seo WD BMB Rep 2016[Sep]; 49 (9): 508-13 PMID27439603show ga Hypoxia-inducible factor (HIF)-1alpha is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1alpha regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1alpha inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1alpha and downregulated Akt signaling without affecting the stability of HIF-1alpha protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. [BMB Reports 2016; 49(9): 508-513]. |Atractylodes/chemistry/metabolism[MESH] |Blotting, Western[MESH] |Chorioallantoic Membrane/drug effects/physiology[MESH] |Cobalt/toxicity[MESH] |Down-Regulation/drug effects[MESH] |Enediynes/*pharmacology[MESH] |HeLa Cells[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism[MESH] |Neovascularization, Physiologic/*drug effects[MESH] |Phosphorylation/drug effects[MESH] |Proto-Oncogene Proteins c-akt/*metabolism[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Signal Transduction/*drug effects[MESH]Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol(epmc).pdf DeepDyve Pubget Overpricing