Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/acsmedchemlett.6b00120 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.6b00120 27437079/?report=reader!4948012!27437079     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2016 ; 7 (7): 692-6 Nephropedia Template TP {{tp|p=27437079|t=2016. Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens |pdf=|usr=}}{{27437079}} gab.com Text Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27437079 #FOAvip Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we report a new class of charged propargyl-linked antifolates that capture some of the key contacts common to the classical antifolates while maintaining the ability to passively diffuse across the bacterial cell wall. Eight synthesized compounds exhibit extraordinary potency against Gram-positive S. aureus with limited toxicity against mammalian cells and good metabolic profile. High resolution crystal structures of two of the compounds reveal extensive interactions between the carboxylate and active site residues through a highly organized water network. Twit Text FOAVip Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27437079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27437079 #FOAvip English Wikipedia <ref>{{Cite pmid|27437079}}</ref> Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens #MMPMID27437079 Scocchera E; Reeve SM; Keshipeddy S; Lombardo MN; Hajian B; Sochia AE; Alverson JB; Priestley ND; Anderson AC; Wright DL ACS Med Chem Lett 2016[Jul]; 7 (7): 692-6 PMID27437079show ga Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we report a new class of charged propargyl-linked antifolates that capture some of the key contacts common to the classical antifolates while maintaining the ability to passively diffuse across the bacterial cell wall. Eight synthesized compounds exhibit extraordinary potency against Gram-positive S. aureus with limited toxicity against mammalian cells and good metabolic profile. High resolution crystal structures of two of the compounds reveal extensive interactions between the carboxylate and active site residues through a highly organized water network. äCharged Nonclassical Antifolates with Activity Against Gram-Positive a(epmc).pdf DeepDyve Pubget Overpricing