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10.1111/ane.12614

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suck abstract from ncbi


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pmid27241213      Acta+Neurol+Scand 2017 ; 135 (4): 407-411
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  • Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson s disease #MMPMID27241213
  • Williams NR; Bentzley BS; Sahlem GL; Pannu J; Korte JE; Revuelta G; Short EB; George MS
  • Acta Neurol Scand 2017[Apr]; 135 (4): 407-411 PMID27241213show ga
  • OBJECTIVES: Electroconvulsive therapy (ECT) has demonstrated efficacy in treating core symptoms of Parkinson's disease (PD); however, widespread use of ECT in PD has been limited due to concern over cognitive burden. We investigated the use of a newer ECT technology known to have fewer cognitive side effects (right unilateral [RUL] ultra-brief pulse [UBP]) for the treatment of medically refractory psychiatric dysfunction in PD. MATERIALS AND METHODS: This open-label pilot study included 6 patients who were assessed in the motoric, cognitive, and neuropsychiatric domains prior to and after RUL UBP ECT. Primary endpoints were changes in total score on the HAM-D-17 and GDS-30 rating scales. RESULTS: Patients were found to improve in motoric and psychiatric domains following RUL UBP ECT without cognitive side effects, both immediately following ECT and at 1-month follow-up. CONCLUSIONS: This study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects.
  • |Aged[MESH]
  • |Depression/etiology/*therapy[MESH]
  • |Electroconvulsive Therapy/*adverse effects[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Parkinson Disease/*complications/therapy[MESH]


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