Electrophysiologist shows a cation channel function of MLKL #MMPMID27229313
Zhang Y; Han J
Cell Res 2016[Jun]; 26 (6): 643-4 PMID27229313show ga
Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.