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10.1186/s13062-016-0128-3 http://scihub22266oqcxt.onion/10.1186/s13062-016-0128-3 27209091/?report=reader!4875738!27209091     free     free     free       Biol+Direct 2016 ; 11 (ä): 26 Nephropedia Template TP {{tp|p=27209091|t=2016. Gene overlapping and size constraints in the viral world |pdf=|usr=}}{{27209091}} gab.com Text Gene overlapping and size constraints in the viral world JO: Biol Direct http://www.kidney.de/pget.php?&tw=1&pmid=27209091 #FOAvip BACKGROUND: Viruses are the simplest replicating units, characterized by a limited number of coding genes and an exceptionally high rate of overlapping genes. We sought a unified evolutionary explanation that accounts for their genome sizes, gene overlapping and capsid properties. RESULTS: We performed an unbiased statistical analysis of ~100 families within ~400 genera that comprise the currently known viral world. We found that the volume utilization of capsids is often low, and greatly varies among viral families. Furthermore, although viruses span three orders of magnitude in genome length, they almost never have over 1500 overlapping nucleotides, or over four significantly overlapping genes per virus. CONCLUSIONS: Our findings undermine the generality of the compression theory, which emphasizes optimal packing and length dependency to explain overlapping genes and capsid size in viral genomes. Instead, we propose that gene novelty and evolution exploration offer better explanations to size constraints and gene overlapping in all viruses. REVIEWERS: This article was reviewed by Arne Elofsson and David Kreil. Twit Text FOAVip Gene overlapping and size constraints in the viral world ????Biol Direct http://www.kidney.de/pget.php?&tw=1&pmid=27209091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27209091 #FOAvip English Wikipedia <ref>{{Cite pmid|27209091}}</ref> Gene overlapping and size constraints in the viral world #MMPMID27209091 Brandes N; Linial M Biol Direct 2016[May]; 11 (ä): 26 PMID27209091show ga BACKGROUND: Viruses are the simplest replicating units, characterized by a limited number of coding genes and an exceptionally high rate of overlapping genes. We sought a unified evolutionary explanation that accounts for their genome sizes, gene overlapping and capsid properties. RESULTS: We performed an unbiased statistical analysis of ~100 families within ~400 genera that comprise the currently known viral world. We found that the volume utilization of capsids is often low, and greatly varies among viral families. Furthermore, although viruses span three orders of magnitude in genome length, they almost never have over 1500 overlapping nucleotides, or over four significantly overlapping genes per virus. CONCLUSIONS: Our findings undermine the generality of the compression theory, which emphasizes optimal packing and length dependency to explain overlapping genes and capsid size in viral genomes. Instead, we propose that gene novelty and evolution exploration offer better explanations to size constraints and gene overlapping in all viruses. REVIEWERS: This article was reviewed by Arne Elofsson and David Kreil. |*Evolution, Molecular[MESH] |*Genes, Overlapping[MESH] |*Genome Size[MESH] |*Genome, Viral[MESH] |Capsid/*physiology[MESH]Gene overlapping and size constraints in the viral world (epmc).pdf DeepDyve Pubget Overpricing