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10.1152/ajprenal.00166.2016

http://scihub22266oqcxt.onion/10.1152/ajprenal.00166.2016
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27147669Pathophysiologyofgadolinium-associatedsystemicfibrosis.!4967166!27147669
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suck abstract from ncbi


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pmid27147669      Am+J+Physiol+Renal+Physiol 2016 ; 311 (1): F1-F11
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  • Pathophysiology of gadolinium-associated systemic fibrosis #MMPMID27147669
  • Wagner B; Drel V; Gorin Y
  • Am J Physiol Renal Physiol 2016[Jul]; 311 (1): F1-F11 PMID27147669show ga
  • Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the threat of litigation has vastly altered clinical practice. Most theories concerning the etiology of the fibrosis are grounded in case reports rather than experiment. This has led to the widely accepted conjecture that the relative affinity of certain contrast agents for the gadolinium ion inversely correlates with the risk of succumbing to the disease. How gadolinium-containing contrast agents trigger widespread and site-specific systemic fibrosis and how chronicity is maintained are largely unknown. This review highlights experimentally-derived information from our laboratory and others that pertain to our understanding of the pathophysiology of gadolinium-associated systemic fibrosis.
  • |Contrast Media/*adverse effects[MESH]
  • |Fibrosis/*chemically induced/epidemiology/pathology[MESH]
  • |Gadolinium/*adverse effects[MESH]
  • |Humans[MESH]


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