Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/apha.12703 http://scihub22266oqcxt.onion/10.1111/apha.12703 27129733!5086442!27129733     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Physiol+(Oxf) 2017 ; 219 (1): 260-273 Nephropedia Template TP {{tp|p=27129733|t=2017. Role and mechanisms of regulation of the basolateral K(ir) 4 1/K(ir) 5 1K(+) channels in the distal tubules |pdf=|usr=}}{{27129733}} gab.com Text Role and mechanisms of regulation of the basolateral K(ir) 4 1/K(ir) 5 1K(+) channels in the distal tubules JO: Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=27129733 #FOAvip Epithelial K(+) channels are essential for maintaining electrolyte and fluid homeostasis in the kidney. It is recognized that basolateral inward-rectifying K(+) (K(ir) ) channels play an important role in the control of resting membrane potential and transepithelial voltage, thereby modulating water and electrolyte transport in the distal part of nephron and collecting duct. Monomeric K(ir) 4.1 (encoded by Kcnj10 gene) and heteromeric K(ir) 4.1/K(ir) 5.1 (K(ir) 4.1 together with K(ir) 5.1 (Kcnj16)) channels are abundantly expressed at the basolateral membranes of the distal convoluted tubule and the cortical collecting duct cells. Loss-of-function mutations in KCNJ10 cause EAST/SeSAME tubulopathy in humans associated with salt wasting, hypomagnesaemia, metabolic alkalosis and hypokalaemia. In contrast, mice lacking K(ir) 5.1 have severe renal phenotype that, apart from hypokalaemia, is the opposite of the phenotype seen in EAST/SeSAME syndrome. Experimental advances using genetic animal models provided critical insights into the physiological role of these channels in electrolyte homeostasis and the control of kidney function. Here, we discuss current knowledge about K(+) channels at the basolateral membrane of the distal tubules with specific focus on the homomeric K(ir) 4.1 and heteromeric K(ir) 4.1/K(ir) 5.1 channels. Recently identified molecular mechanisms regulating expression and activity of these channels, such as cell acidification, dopamine, insulin and insulin-like growth factor-1, Src family protein tyrosine kinases, as well as the role of these channels in NCC-mediated transport in the distal convoluted tubules, are also described. Twit Text FOAVip Role and mechanisms of regulation of the basolateral K(ir) 4 1/K(ir) 5 1K(+) channels in the distal tubules ????Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=27129733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27129733 #FOAvip English Wikipedia <ref>{{Cite pmid|27129733}}</ref> Role and mechanisms of regulation of the basolateral K(ir) 4 1/K(ir) 5 1K(+) channels in the distal tubules #MMPMID27129733 Palygin O; Pochynyuk O; Staruschenko A Acta Physiol (Oxf) 2017[Jan]; 219 (1): 260-273 PMID27129733show ga Epithelial K(+) channels are essential for maintaining electrolyte and fluid homeostasis in the kidney. It is recognized that basolateral inward-rectifying K(+) (K(ir) ) channels play an important role in the control of resting membrane potential and transepithelial voltage, thereby modulating water and electrolyte transport in the distal part of nephron and collecting duct. Monomeric K(ir) 4.1 (encoded by Kcnj10 gene) and heteromeric K(ir) 4.1/K(ir) 5.1 (K(ir) 4.1 together with K(ir) 5.1 (Kcnj16)) channels are abundantly expressed at the basolateral membranes of the distal convoluted tubule and the cortical collecting duct cells. Loss-of-function mutations in KCNJ10 cause EAST/SeSAME tubulopathy in humans associated with salt wasting, hypomagnesaemia, metabolic alkalosis and hypokalaemia. In contrast, mice lacking K(ir) 5.1 have severe renal phenotype that, apart from hypokalaemia, is the opposite of the phenotype seen in EAST/SeSAME syndrome. Experimental advances using genetic animal models provided critical insights into the physiological role of these channels in electrolyte homeostasis and the control of kidney function. Here, we discuss current knowledge about K(+) channels at the basolateral membrane of the distal tubules with specific focus on the homomeric K(ir) 4.1 and heteromeric K(ir) 4.1/K(ir) 5.1 channels. Recently identified molecular mechanisms regulating expression and activity of these channels, such as cell acidification, dopamine, insulin and insulin-like growth factor-1, Src family protein tyrosine kinases, as well as the role of these channels in NCC-mediated transport in the distal convoluted tubules, are also described. |*Gene Expression Regulation[MESH] |Animals[MESH] |Cell Membrane/metabolism[MESH] |Kidney Tubules, Distal/*metabolism[MESH] |Kir5.1 Channel[MESH] |Membrane Potentials/physiology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Nephrons/metabolism[MESH]Role and mechanisms of regulation of the basolateral K(ir) 4 1/K(ir) 5(epmc).pdf DeepDyve Pubget Overpricing