Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2016.04.002 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.002 27117419!ä!27117419 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27117419.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2016 ; 15 (5): 1076-1087 Nephropedia Template TP {{tp|p=27117419|t=2016. Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses |pdf=|usr=}}{{27117419}} gab.com Text Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27117419 #FOAvip The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation. Twit Text FOAVip Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27117419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27117419 #FOAvip English Wikipedia <ref>{{Cite pmid|27117419}}</ref> Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses #MMPMID27117419 Loi M; Muller A; Steinbach K; Niven J; Barreira da Silva R; Paul P; Ligeon LA; Caruso A; Albrecht RA; Becker AC; Annaheim N; Nowag H; Dengjel J; Garcia-Sastre A; Merkler D; Munz C; Gannage M Cell Rep 2016[May]; 15 (5): 1076-1087 PMID27117419show ga The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation. |Animals[MESH] |Antigen Presentation/immunology[MESH] |Autophagy-Related Protein 5/*genetics[MESH] |Autophagy-Related Protein 7/*genetics[MESH] |Autophagy/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Cells, Cultured[MESH] |Dendritic Cells/*immunology[MESH] |Endocytosis/immunology[MESH] |Histocompatibility Antigens Class I/*immunology[MESH] |Histocompatibility Antigens Class II/immunology[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/*immunology[MESH] |Lymphocyte Activation/immunology[MESH] |Lymphocytic choriomeningitis virus/*immunology[MESH] |Macrophages/immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH]Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells (epmc).pdf DeepDyve Pubget Overpricing