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10.1080/2162402X.2015.1004983 http://scihub22266oqcxt.onion/10.1080/2162402X.2015.1004983 27057424!4801459!27057424     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27057424&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncoimmunology 2016 ; 5 (2): e1004983 Nephropedia Template TP {{tp|p=27057424|t=2016. Phenotype, development, and biological function of myeloid-derived suppressor cells |pdf=|usr=}}{{27057424}} gab.com Text Phenotype, development, and biological function of myeloid-derived suppressor cells JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27057424 #FOAvip CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) are an important population of innate regulatory cells mainly comprising monocytic MDSCs (M-MDSCs) with a phenotype of CD11b(+)Ly6G(-)Ly6C(high) and granulocytic MDSCs (G-MDSCs) with a phenotype of CD11b(+)Ly6G(+)Ly6C(low) in mice. They play crucial roles in the pathogenesis of cancers, chronic infections, autoimmune diseases, and transplantation. Various extracellular factors such as lipopolysaccharide (LPS), macrophage colony-stimulating factor (M-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), stem cell factor (SCF), interleukin (IL)-6, interferon gamma (IFNgamma), IL-1beta, vascular endothelial growth factor (VEGF), Hsp72, IL-13, C5a, and prostaglandin E2 (PGE2) can induce MDSC differentiation, whereas IL-4 and all-trans-retinoic acid can inhibit this process. For the intracellular signals, signal transducer and activator of transcription (STAT) family members, C/EBPbeta and cyclooxigenase-2 (COX-2) promote MDSC function, whereas interferon regulatory factor-8 (IRF-8) and Smad3 downregulate MDSC activity. The immunosuppressive function of MDSCs is mediated through various effector molecules, primarily cellular metabolism-related molecules such as nitric oxide (NO), arginase, reactive oxygen species (ROS), transforming growth factor beta (TGFbeta), IL-10, indoleamine 2,3-dioxygenase (IDO), heme oxygenase-1 (HO-1), carbon monoxide (CO), and PGE2. In this article, we will summarize the molecules involved in the induction and function of MDSCs as well as the regulatory pathways of MDSCs. Twit Text FOAVip Phenotype, development, and biological function of myeloid-derived suppressor cells ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27057424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27057424 #FOAvip English Wikipedia <ref>{{Cite pmid|27057424}}</ref> Phenotype, development, and biological function of myeloid-derived suppressor cells #MMPMID27057424 Zhao Y; Wu T; Shao S; Shi B; Zhao Y Oncoimmunology 2016[Feb]; 5 (2): e1004983 PMID27057424show ga CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) are an important population of innate regulatory cells mainly comprising monocytic MDSCs (M-MDSCs) with a phenotype of CD11b(+)Ly6G(-)Ly6C(high) and granulocytic MDSCs (G-MDSCs) with a phenotype of CD11b(+)Ly6G(+)Ly6C(low) in mice. They play crucial roles in the pathogenesis of cancers, chronic infections, autoimmune diseases, and transplantation. Various extracellular factors such as lipopolysaccharide (LPS), macrophage colony-stimulating factor (M-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), stem cell factor (SCF), interleukin (IL)-6, interferon gamma (IFNgamma), IL-1beta, vascular endothelial growth factor (VEGF), Hsp72, IL-13, C5a, and prostaglandin E2 (PGE2) can induce MDSC differentiation, whereas IL-4 and all-trans-retinoic acid can inhibit this process. For the intracellular signals, signal transducer and activator of transcription (STAT) family members, C/EBPbeta and cyclooxigenase-2 (COX-2) promote MDSC function, whereas interferon regulatory factor-8 (IRF-8) and Smad3 downregulate MDSC activity. The immunosuppressive function of MDSCs is mediated through various effector molecules, primarily cellular metabolism-related molecules such as nitric oxide (NO), arginase, reactive oxygen species (ROS), transforming growth factor beta (TGFbeta), IL-10, indoleamine 2,3-dioxygenase (IDO), heme oxygenase-1 (HO-1), carbon monoxide (CO), and PGE2. In this article, we will summarize the molecules involved in the induction and function of MDSCs as well as the regulatory pathways of MDSCs. ?Phenotype, development, and biological function of myeloid-derived sup(epmc).pdf DeepDyve Pubget Overpricing