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10.1007/s12576-016-0449-0 http://scihub22266oqcxt.onion/10.1007/s12576-016-0449-0 27043350!10717052!27043350     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Physiol+Sci 2017 ; 67 (1): 151-162 Nephropedia Template TP {{tp|p=27043350|t=2017. Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport |pdf=|usr=}}{{27043350}} gab.com Text Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport JO: J Physiol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27043350 #FOAvip The placenta is required to transport calcium (Ca(2+)) from mother to fetus during fetal bone mineralization. In an attempt to clarify the molecular basis of Ca(2+) entry for this transport, we identified TRPM6 as a candidate for apical Ca(2+) entry pathway. TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization. Plasma membrane Ca(2+) permeability was significantly increased in TRPM6/TRPM7 expressed HEK293 cells under physiological Mg(2+) and ATP concentration but not in TRPM6 or TRPM7 homomer-expressing cells. These results suggest that TRPM6 is functionally expressed in mouse placental trophoblasts, implicating in maternal-fetal Ca(2+) transport likely with TRPM7, which might enable to sustain fetal bone mineralization. Twit Text FOAVip Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport ????J Physiol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27043350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27043350 #FOAvip English Wikipedia <ref>{{Cite pmid|27043350}}</ref> Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport #MMPMID27043350 Suzuki Y; Watanabe M; Saito CT; Tominaga M J Physiol Sci 2017[Jan]; 67 (1): 151-162 PMID27043350show ga The placenta is required to transport calcium (Ca(2+)) from mother to fetus during fetal bone mineralization. In an attempt to clarify the molecular basis of Ca(2+) entry for this transport, we identified TRPM6 as a candidate for apical Ca(2+) entry pathway. TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization. Plasma membrane Ca(2+) permeability was significantly increased in TRPM6/TRPM7 expressed HEK293 cells under physiological Mg(2+) and ATP concentration but not in TRPM6 or TRPM7 homomer-expressing cells. These results suggest that TRPM6 is functionally expressed in mouse placental trophoblasts, implicating in maternal-fetal Ca(2+) transport likely with TRPM7, which might enable to sustain fetal bone mineralization. |Animals[MESH] |Calcium/*metabolism[MESH] |Cell Membrane Permeability/physiology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Ion Transport/physiology[MESH] |Maternal-Fetal Exchange/*physiology[MESH] |Mice[MESH] |Placenta/*metabolism[MESH] |Pregnancy[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]Expression of the TRPM6 in mouse placental trophoblasts; potential rol(epmc).pdf DeepDyve Pubget Overpricing