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10.1152/ajprenal.00117.2016 http://scihub22266oqcxt.onion/10.1152/ajprenal.00117.2016 27029425!4935772!27029425     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27029425&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Am+J+Physiol+Renal+Physiol 2016 ; 310 (11): F1157-67 Nephropedia Template TP {{tp|p=27029425|t=2016. Calcium-permeable ion channels in the kidney |pdf=|usr=}}{{27029425}} gab.com Text Calcium-permeable ion channels in the kidney JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27029425 #FOAvip Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reabsorption. Approximately 60% of the Ca(2+) in plasma is filtered, and 99% of that is reabsorbed by the kidney tubules. Ca(2+) is also a critical signaling molecule in kidney development, in all kidney cellular functions, and in the emergence of kidney diseases. Recently, studies using genetic and molecular biological approaches have identified several Ca(2+)-permeable ion channel families as important regulators of Ca(2+) homeostasis in kidney. These ion channel families include transient receptor potential channels (TRP), voltage-gated calcium channels, and others. In this review, we provide a brief and systematic summary of the expression, function, and pathological contribution for each of these Ca(2+)-permeable ion channels. Moreover, we discuss their potential as future therapeutic targets. Twit Text FOAVip Calcium-permeable ion channels in the kidney ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27029425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27029425 #FOAvip English Wikipedia <ref>{{Cite pmid|27029425}}</ref> Calcium-permeable ion channels in the kidney #MMPMID27029425 Zhou Y; Greka A Am J Physiol Renal Physiol 2016[Jun]; 310 (11): F1157-67 PMID27029425show ga Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reabsorption. Approximately 60% of the Ca(2+) in plasma is filtered, and 99% of that is reabsorbed by the kidney tubules. Ca(2+) is also a critical signaling molecule in kidney development, in all kidney cellular functions, and in the emergence of kidney diseases. Recently, studies using genetic and molecular biological approaches have identified several Ca(2+)-permeable ion channel families as important regulators of Ca(2+) homeostasis in kidney. These ion channel families include transient receptor potential channels (TRP), voltage-gated calcium channels, and others. In this review, we provide a brief and systematic summary of the expression, function, and pathological contribution for each of these Ca(2+)-permeable ion channels. Moreover, we discuss their potential as future therapeutic targets. |Animals[MESH] |Calcium Channels/*metabolism[MESH] |Calcium Signaling/*physiology[MESH] |Calcium/*metabolism[MESH] |Humans[MESH] |Kidney Diseases/metabolism[MESH] |Kidney/*metabolism[MESH]Calcium-permeable ion channels in the kidney (epmc).pdf DeepDyve Pubget Overpricing