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10.18632/aging.100913 http://scihub22266oqcxt.onion/10.18632/aging.100913 26946062/?report=reader!4833143!26946062     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2016 ; 8 (3): 521-33 Nephropedia Template TP {{tp|p=26946062|t=2016. Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of beta-amyloid |pdf=|usr=}}{{26946062}} gab.com Text Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of beta-amyloid JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=26946062 #FOAvip Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD. Twit Text FOAVip Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of beta-amyloid ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=26946062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26946062 #FOAvip English Wikipedia <ref>{{Cite pmid|26946062}}</ref> Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of beta-amyloid #MMPMID26946062 Li Y; Yuan X; Shen Y; Zhao J; Yue R; Liu F; He W; Wang R; Shan L; Zhang W Aging (Albany NY) 2016[Mar]; 8 (3): 521-33 PMID26946062show ga Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD. |*Bacopa[MESH] |*Phytotherapy[MESH] |Alzheimer Disease/*drug therapy/immunology/metabolism[MESH] |Amyloid beta-Peptides/*drug effects/immunology/metabolism[MESH] |Animals[MESH] |Blotting, Western[MESH] |Disease Models, Animal[MESH] |Male[MESH] |Memory/drug effects[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Proteome[MESH] |Saponins/pharmacology/*therapeutic use[MESH]Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immu(epmc).pdf DeepDyve Pubget Overpricing