Beyond the gut bacterial microbiota: The gut virome #MMPMID26919534
Columpsi P; Sacchi P; Zuccaro V; Cima S; Sarda C; Mariani M; Gori A; Bruno R
J Med Virol 2016[Sep]; 88 (9): 1467-72 PMID26919534show ga
The gastrointestinal tract is colonized with a highly different population of bacterial, viral, ad fungal species; viruses are reported to be dominant. The composition of gut virome is closely related to dietary habits and surrounding environment. Host and their intestinal microbes live in a dynamic equilibrium and viruses stimulate a low degree of immune responses without causing symptoms (host tolerance). However, intestinal phages could lead to a rupture of eubiosis and may contribute to the shift from health to disease in humans and animals. Viral nucleic acids and other products of lysis of bacteria serve as pathogen-associated molecular patterns (PAMPs) and could trigger specific inflammatory modulations. At the same time, phages could elicit innate antiviral immune responses. Toll-like receptors (TLRs) operated as innate antiviral immune sensors and their activation triggers signaling cascades that lead to inflammatory response. J. Med. Virol. 88:1467-1472, 2016. (c) 2016 Wiley Periodicals, Inc.
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J+Med+Virol 2016 ; 88 (9): 1467-72
