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10.1208/s12248-016-9887-0

http://scihub22266oqcxt.onion/10.1208/s12248-016-9887-0
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26902302AggregationKineticsforIgG1-BasedMonoclonalAntibodyTherapeutics.!5256606!26902302; 1
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suck abstract from ncbi


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pmid26902302; 1      AAPS+J;+Biochem+Med 2016 ; 18; 13 (3; 2): 689-702; 117-26
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  • Aggregation Kinetics for IgG1-Based Monoclonal Antibody Therapeutics ; Formate assay in body fluids: application in methanol poisoning #MMPMID26902302; 1
  • Singla A; Bansal R; Joshi V; Rathore AS; Makar AB; McMartin KE; Palese M; Tephly TR
  • AAPS J; Biochem Med 2016[May]; 18; 13 (3; 2): 689-702; 117-26 PMID26902302; 1show ga
  • Monoclonal antibodies (mAbs) as a class of therapeutic molecules are finding an increasing demand in the biotechnology industry for the treatment of diseases like cancer and multiple sclerosis. A key challenge associated to successful commercialization of mAbs is that from the various physical and chemical instabilities that are inherent to these molecules. Out of all probable instabilities, aggregation of mAbs has been a major problem that has been associated with a change in the protein structure and is a hurdle in various upstream and downstream processes. It can stimulate immune response causing protein misfolding having deleterious and harmful effects inside a cell. Also, the extra cost incurred to remove aggregated mAbs from the rest of the batch is huge. Size exclusion chromatography (SEC) is a major technique for characterizing aggregation in mAbs where change in the aggregates' size over time is estimated. The current project is an attempt to understand the rate and mechanism of formation of higher order oligomers when subjected to different environmental conditions such as buffer type, temperature, pH, and salt concentration. The results will be useful in avoiding the product exposure to conditions that can induce aggregation during upstream, downstream, and storage process. Extended Lumry-Eyring model (ELE), Lumry-Eyring Native Polymerization model (LENP), and Finke-Watzky model (F-W) have been employed in this work to fit the aggregation experimental data and results are compared to find the best fit model for mAb aggregation to connect the theoretical dots with the reality.
  • |Aldehyde Oxidoreductases/metabolism[MESH]
  • |Animals[MESH]
  • |Antibodies, Monoclonal/chemistry/*pharmacokinetics[MESH]
  • |Body Fluids/*analysis[MESH]
  • |Carbon Dioxide/blood[MESH]
  • |Chemistry, Pharmaceutical/*methods[MESH]
  • |Formates/blood/*poisoning[MESH]
  • |Haplorhini[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Immunoglobulin G/chemistry/*metabolism[MESH]
  • |Kinetics[MESH]
  • |Methanol/blood[MESH]
  • |Methods[MESH]
  • |Protein Aggregates/*physiology[MESH]


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