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10.1002/1873-3468.12088 http://scihub22266oqcxt.onion/10.1002/1873-3468.12088 26900082!ä!26900082 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26900082&cmd=llinks): Failed to open stream: HTTP request failed! 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TRPM7 channel regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells via MEK-ERK pathways |pdf=|usr=}}{{26900082}} gab.com Text TRPM7 channel regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells via MEK-ERK pathways JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=26900082 #FOAvip Transient receptor potential melastatin 7 (TRPM7) plays a key role in the pathophysiological response of multiple cell types. However, the role of TRPM7 channels in ox-LDL-induced proliferation and migration of VSMC remains unclear. This study used the thoracic aorta VSMCs to explore the effects of ox-LDL on cell proliferation and migration and to investigate the underlying molecular mechanisms and signaling pathways. Data demonstrated that ox-LDL significantly increased TRPM7 activity, and induced VSMC proliferation and migration. VSMC proliferation and migration were inhibited by nonspecific TRPM7 blocker 2-APB or synthetic siRNA targeting TRPM7. Furthermore, the phosphorylation of ERK1/2 and MEK1/2 associated with cell proliferation and migration decreased in TRPM7-deficient VSMC. Therefore, TRPM7 may constitute a useful target for the treatment of atherosclerosis. Twit Text FOAVip TRPM7 channel regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells via MEK-ERK pathways ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=26900082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26900082 #FOAvip English Wikipedia <ref>{{Cite pmid|26900082}}</ref> TRPM7 channel regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells via MEK-ERK pathways #MMPMID26900082 Lin J; Zhou S; Zhao T; Ju T; Zhang L FEBS Lett 2016[Feb]; 590 (4): 520-32 PMID26900082show ga Transient receptor potential melastatin 7 (TRPM7) plays a key role in the pathophysiological response of multiple cell types. However, the role of TRPM7 channels in ox-LDL-induced proliferation and migration of VSMC remains unclear. This study used the thoracic aorta VSMCs to explore the effects of ox-LDL on cell proliferation and migration and to investigate the underlying molecular mechanisms and signaling pathways. Data demonstrated that ox-LDL significantly increased TRPM7 activity, and induced VSMC proliferation and migration. VSMC proliferation and migration were inhibited by nonspecific TRPM7 blocker 2-APB or synthetic siRNA targeting TRPM7. Furthermore, the phosphorylation of ERK1/2 and MEK1/2 associated with cell proliferation and migration decreased in TRPM7-deficient VSMC. Therefore, TRPM7 may constitute a useful target for the treatment of atherosclerosis. |*Cell Movement[MESH] |Animals[MESH] |Aorta, Thoracic/cytology[MESH] |Atherosclerosis/metabolism[MESH] |Boron Compounds/pharmacology[MESH] |Cell Proliferation[MESH] |Cells, Cultured[MESH] |Lipoproteins, LDL/*metabolism[MESH] |MAP Kinase Signaling System[MESH] |Male[MESH] |Muscle, Smooth, Vascular/*cytology/drug effects/metabolism[MESH] |Myocytes, Smooth Muscle/*cytology/drug effects/metabolism[MESH] |Phosphorylation[MESH] |RNA, Small Interfering/genetics[MESH] |Rats[MESH]TRPM7 channel regulates ox-LDL-induced proliferation and migration of (epmc).pdf DeepDyve Pubget Overpricing