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10.1016/j.bbrc.2016.01.140 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2016.01.140 26826385!?!26826385 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26826385&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochem+Biophys+Res+Commun 2016 ; 471 (1): 205-12 Nephropedia Template TP {{tp|p=26826385|t=2016. Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell |pdf=|usr=}}{{26826385}} gab.com Text Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=26826385 #FOAvip Hypoxia promotes cancer progression, and metastasis. The major protein expressed in hypoxic solid cancer is hypoxia-inducible factor 1 (HIF1). We show that enhanced phosphorylation of a conventional protein kinase C isoform, PKCalpha, at threonine 638 (T(638)) by hypoxia-mimetic cobalt chloride induces HIF1alpha in nuclei of gastric epithelial cells (GECs). Moreover, phospho-T(638)-PKCalpha (P-PKCalpha) interacts with p300-HIF1alpha complex in the nuclei of hypoxic GECs and PKCalpha phosphorylation at T(638) enhances transcriptional activity of HIF1alpha. High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression. Twit Text FOAVip Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=26826385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26826385 #FOAvip English Wikipedia <ref>{{Cite pmid|26826385}}</ref> Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell #MMPMID26826385 Rath S; Anand A; Ghosh N; Das L; Kokate SB; Dixit P; Majhi S; Rout N; Singh SP; Bhattacharyya A Biochem Biophys Res Commun 2016[Feb]; 471 (1): 205-12 PMID26826385show ga Hypoxia promotes cancer progression, and metastasis. The major protein expressed in hypoxic solid cancer is hypoxia-inducible factor 1 (HIF1). We show that enhanced phosphorylation of a conventional protein kinase C isoform, PKCalpha, at threonine 638 (T(638)) by hypoxia-mimetic cobalt chloride induces HIF1alpha in nuclei of gastric epithelial cells (GECs). Moreover, phospho-T(638)-PKCalpha (P-PKCalpha) interacts with p300-HIF1alpha complex in the nuclei of hypoxic GECs and PKCalpha phosphorylation at T(638) enhances transcriptional activity of HIF1alpha. High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression. |Cell Hypoxia/drug effects/physiology[MESH] |Cell Line[MESH] |Cell Nucleus/drug effects/*metabolism[MESH] |Cells, Cultured[MESH] |Cobalt/*administration & dosage[MESH] |Dose-Response Relationship, Drug[MESH] |Gastric Mucosa/drug effects/*metabolism[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism[MESH] |Phosphorylation/drug effects/physiology[MESH]Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylat(epmc).pdf DeepDyve Pubget Overpricing