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Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochem+Biophys+Res+Commun 2016 ; 471 (1): 205-12 Nephropedia Template TP
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Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell #MMPMID26826385
Rath S; Anand A; Ghosh N; Das L; Kokate SB; Dixit P; Majhi S; Rout N; Singh SP; Bhattacharyya A
Biochem Biophys Res Commun 2016[Feb]; 471 (1): 205-12 PMID26826385show ga
Hypoxia promotes cancer progression, and metastasis. The major protein expressed in hypoxic solid cancer is hypoxia-inducible factor 1 (HIF1). We show that enhanced phosphorylation of a conventional protein kinase C isoform, PKCalpha, at threonine 638 (T(638)) by hypoxia-mimetic cobalt chloride induces HIF1alpha in nuclei of gastric epithelial cells (GECs). Moreover, phospho-T(638)-PKCalpha (P-PKCalpha) interacts with p300-HIF1alpha complex in the nuclei of hypoxic GECs and PKCalpha phosphorylation at T(638) enhances transcriptional activity of HIF1alpha. High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.