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10.14218/JCTH.2015.00024 http://scihub22266oqcxt.onion/10.14218/JCTH.2015.00024 26807383!4721895!26807383     free     free     free       J+Clin+Transl+Hepatol 2015 ; 3 (4): 271-6 Nephropedia Template TP {{tp|p=26807383|t=2015. IL-6 Plays a Crucial Role in HBV Infection |pdf=|usr=}}{{26807383}} gab.com Text IL-6 Plays a Crucial Role in HBV Infection JO: J Clin Transl Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26807383 #FOAvip Interleukin-6 (IL-6), a cytokine mainly produced by activated monocytes, has broad pleiotropic actions that affect the functions of a variety of lymphoid cells. The roles of IL-6 in regulating immunity to infections are currently being defined. Remarkably, IL-6-mediated cellular and humoral immune responses play a crucial role in determining the outcome of viral infection. This article reviews the current knowledge on the critical role of IL-6 in hepatitis B virus (HBV) infection. As a competent intermediary, IL-6 derived from activated monocytes plays an important role in promoting lymphocytes responses that are essential for effective viral control. However, as a mediator of inflammation, IL-6 is also involved in the development of HBV-induced liver cirrhosis and exacerbating liver injury. Overall, the current data point to IL-6 as an immunoregulatory cytokine in HBV infection. Immunotherapeutic strategies aimed at optimizing the beneficial effects of IL-6 in HBV infection may prove to be an ordeal in the future, as they should foster the strengths of IL-6 while circumventing potential drawbacks. Twit Text FOAVip IL-6 Plays a Crucial Role in HBV Infection ????J Clin Transl Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26807383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26807383 #FOAvip English Wikipedia <ref>{{Cite pmid|26807383}}</ref> IL-6 Plays a Crucial Role in HBV Infection #MMPMID26807383 Lan T; Chang L; Wu L; Yuan YF J Clin Transl Hepatol 2015[Dec]; 3 (4): 271-6 PMID26807383show ga Interleukin-6 (IL-6), a cytokine mainly produced by activated monocytes, has broad pleiotropic actions that affect the functions of a variety of lymphoid cells. The roles of IL-6 in regulating immunity to infections are currently being defined. Remarkably, IL-6-mediated cellular and humoral immune responses play a crucial role in determining the outcome of viral infection. This article reviews the current knowledge on the critical role of IL-6 in hepatitis B virus (HBV) infection. As a competent intermediary, IL-6 derived from activated monocytes plays an important role in promoting lymphocytes responses that are essential for effective viral control. However, as a mediator of inflammation, IL-6 is also involved in the development of HBV-induced liver cirrhosis and exacerbating liver injury. Overall, the current data point to IL-6 as an immunoregulatory cytokine in HBV infection. Immunotherapeutic strategies aimed at optimizing the beneficial effects of IL-6 in HBV infection may prove to be an ordeal in the future, as they should foster the strengths of IL-6 while circumventing potential drawbacks. ?IL-6 Plays a Crucial Role in HBV Infection (epmc).pdf DeepDyve Pubget Overpricing