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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Antiviral+Res 2016 ; 126 (ä): 69-80 Nephropedia Template TP
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Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine #MMPMID26738783
Soderholm S; Anastasina M; Islam MM; Tynell J; Poranen MM; Bamford DH; Stenman J; Julkunen I; Sauliene I; De Brabander JK; Matikainen S; Nyman TA; Saelens X; Kainov D
Antiviral Res 2016[Feb]; 126 (ä): 69-80 PMID26738783show ga
Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFNalpha)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections.
Antiviral+Res 2016 ; 126 (ä): 69-80
