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10.1038/srep18710 http://scihub22266oqcxt.onion/10.1038/srep18710 26732173!4702109!26732173     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26732173&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): 18710 Nephropedia Template TP {{tp|p=26732173|t=2016. Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway |pdf=|usr=}}{{26732173}} gab.com Text Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26732173 #FOAvip The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling pathway for triggering pseudohypoaldosteronism type II (PHAII), an autosomal dominant hereditary disease that is characterized by hypertension. However, the molecular mechanism(s) by which the WNK-SPAK/OSR1 pathway is regulated remain unclear. In this report, we identified WNK4 as an interacting partner of a recently identified MAP3K, apoptosis signal-regulating kinase 3 (ASK3). We found that WNK4 is phosphorylated in an ASK3 kinase activity-dependent manner. By exploring the ASK3-dependent phosphorylation sites, we identified Ser575 as a novel phosphorylation site in WNK4 by LC-MS/MS analysis. ASK3-dependent WNK4 Ser575 phosphorylation was mediated by the p38MAPK-MAPK-activated protein kinase (MK) pathway. Osmotic stress, as well as hypotonic low-chloride stimulation, increased WNK4 Ser575 phosphorylation via the p38MAPK-MK pathway. ASK3 was required for the p38MAPK activation induced by hypotonic stimulation but was not required for that induced by hypertonic stimulation or hypotonic low-chloride stimulation. Our results suggest that the p38MAPK-MK pathway might regulate WNK4 in an osmotic stress-dependent manner but its upstream regulators might be divergent depending on the types of osmotic stimuli. Twit Text FOAVip Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26732173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26732173 #FOAvip English Wikipedia <ref>{{Cite pmid|26732173}}</ref> Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway #MMPMID26732173 Maruyama J; Kobayashi Y; Umeda T; Vandewalle A; Takeda K; Ichijo H; Naguro I Sci Rep 2016[Jan]; 6 (ä): 18710 PMID26732173show ga The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling pathway for triggering pseudohypoaldosteronism type II (PHAII), an autosomal dominant hereditary disease that is characterized by hypertension. However, the molecular mechanism(s) by which the WNK-SPAK/OSR1 pathway is regulated remain unclear. In this report, we identified WNK4 as an interacting partner of a recently identified MAP3K, apoptosis signal-regulating kinase 3 (ASK3). We found that WNK4 is phosphorylated in an ASK3 kinase activity-dependent manner. By exploring the ASK3-dependent phosphorylation sites, we identified Ser575 as a novel phosphorylation site in WNK4 by LC-MS/MS analysis. ASK3-dependent WNK4 Ser575 phosphorylation was mediated by the p38MAPK-MAPK-activated protein kinase (MK) pathway. Osmotic stress, as well as hypotonic low-chloride stimulation, increased WNK4 Ser575 phosphorylation via the p38MAPK-MK pathway. ASK3 was required for the p38MAPK activation induced by hypotonic stimulation but was not required for that induced by hypertonic stimulation or hypotonic low-chloride stimulation. Our results suggest that the p38MAPK-MK pathway might regulate WNK4 in an osmotic stress-dependent manner but its upstream regulators might be divergent depending on the types of osmotic stimuli. |*Osmotic Pressure[MESH] |*Signal Transduction[MESH] |Adaptor Proteins, Signal Transducing[MESH] |Amino Acids/metabolism[MESH] |Carrier Proteins/metabolism[MESH] |Cell Line[MESH] |Enzyme Activation[MESH] |Gene Expression[MESH] |Humans[MESH] |MAP Kinase Kinase Kinases/genetics/metabolism[MESH] |Microfilament Proteins[MESH] |Phosphorylation[MESH] |Protein Binding[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH]Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38M(epmc).pdf DeepDyve Pubget Overpricing