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10.1021/acs.jmedchem.5b01509 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.5b01509 26730678!ä!26730678 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Chem 2016 ; 59 (2): 756-62 Nephropedia Template TP {{tp|p=26730678|t=2016. Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo |pdf=|usr=}}{{26730678}} gab.com Text Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26730678 #FOAvip The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules (HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression, liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue HO-1 and delivered CO in blood after administration in vivo, supporting their potential use against inflammatory conditions. Twit Text FOAVip Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26730678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26730678 #FOAvip English Wikipedia <ref>{{Cite pmid|26730678}}</ref> Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo #MMPMID26730678 Nikam A; Ollivier A; Rivard M; Wilson JL; Mebarki K; Martens T; Dubois-Rande JL; Motterlini R; Foresti R J Med Chem 2016[Jan]; 59 (2): 756-62 PMID26730678show ga The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules (HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression, liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue HO-1 and delivered CO in blood after administration in vivo, supporting their potential use against inflammatory conditions. |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis/pharmacology[MESH] |Carbon Monoxide/blood/chemistry/*metabolism[MESH] |Carboxyhemoglobin/metabolism[MESH] |Cell Line[MESH] |Cell Survival[MESH] |Cobalt/*chemistry[MESH] |Enzyme Activation/drug effects[MESH] |Enzyme Induction/drug effects[MESH] |Glutathione/biosynthesis[MESH] |Heme Oxygenase-1/biosynthesis/*drug effects[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |NF-E2-Related Factor 2/*drug effects[MESH] |Neuroglia/drug effects/metabolism[MESH]Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Ox(epmc).pdf DeepDyve Pubget Overpricing