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10.1002/bies.201500131 http://scihub22266oqcxt.onion/10.1002/bies.201500131 26661048!4749135!26661048     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioessays 2016 ; 38 (1): 21-6 Nephropedia Template TP {{tp|p=26661048|t=2016. Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression |pdf=|usr=}}{{26661048}} gab.com Text Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=26661048 #FOAvip Reading frame maintenance is a critical property of ribosomes. However, a number of genetic elements have been described that can induce ribosomes to shift on mRNAs, the most well understood of which are a class that directs ribosomal slippage by one base in 5' (-1) direction. This is referred to as programmed -1 ribosomal frameshifting (-1 PRF). Recently, a new -1 PRF promoting element was serendipitously discovered in a study examining the effects of stretches of adenosines in the coding sequences of mRNAs. Here, we discuss this finding, recent studies describing how -1 PRF is used to control gene expression in eukaryotes, and how -1 PRF is itself regulated. The implications of dysregulation of -1 PRF on human health are examined, as are possible new areas in which novel -1 PRF promoting elements might be discovered. Also watch the Video Abstract. Twit Text FOAVip Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=26661048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26661048 #FOAvip English Wikipedia <ref>{{Cite pmid|26661048}}</ref> Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression #MMPMID26661048 Advani VM; Dinman JD Bioessays 2016[Jan]; 38 (1): 21-6 PMID26661048show ga Reading frame maintenance is a critical property of ribosomes. However, a number of genetic elements have been described that can induce ribosomes to shift on mRNAs, the most well understood of which are a class that directs ribosomal slippage by one base in 5' (-1) direction. This is referred to as programmed -1 ribosomal frameshifting (-1 PRF). Recently, a new -1 PRF promoting element was serendipitously discovered in a study examining the effects of stretches of adenosines in the coding sequences of mRNAs. Here, we discuss this finding, recent studies describing how -1 PRF is used to control gene expression in eukaryotes, and how -1 PRF is itself regulated. The implications of dysregulation of -1 PRF on human health are examined, as are possible new areas in which novel -1 PRF promoting elements might be discovered. Also watch the Video Abstract. |*Genetic Code[MESH] |Cellular Reprogramming/*genetics[MESH] |Frameshifting, Ribosomal/*genetics[MESH] |Gene Expression Regulation/genetics[MESH] |Humans[MESH] |Protein Biosynthesis/genetics[MESH] |RNA, Messenger/genetics[MESH]Reprogramming the genetic code: The emerging role of ribosomal framesh(epmc).pdf DeepDyve Pubget Overpricing