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10.1111/resp.12685 http://scihub22266oqcxt.onion/10.1111/resp.12685 26638130!4738455!26638130     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respirology 2016 ; 21 (2): 370-7 Nephropedia Template TP {{tp|p=26638130|t=2016. Randomized controlled trial of the effect of regular paracetamol on influenza infection |pdf=|usr=}}{{26638130}} gab.com Text Randomized controlled trial of the effect of regular paracetamol on influenza infection JO: Respirology http://www.kidney.de/pget.php?&tw=1&pmid=26638130 #FOAvip BACKGROUND AND OBJECTIVE: Anti-pyretic treatment is recommended in the management of influenza infection. In animal models anti-pyretic treatment increases mortality from influenza. We investigated the effects of paracetamol on viral and clinical outcomes in adults with influenza infection. METHODS: This is a randomized, double-blind, placebo-controlled trial of adults aged 18-65 years with influenza-like illness and positive influenza rapid antigen test. Treatments were 1 g paracetamol four times a day, or matching placebo, for 5 days. Pernasal swabs were taken for influenza quantitative RT-PCR at Baseline and Days 1, 2 and 5. Temperature and symptom scores were recorded for 5-14 days or time of resolution respectively. The primary outcome variable was area under the curve (AUC) for quantitative PCR log10 viral load from Baseline to Day 5. RESULTS: A total of 80 participants were randomized: no one was lost to follow up, and one withdrew after 4 days. There were 22 and 24 participants who were influenza PCR-positive in placebo and in paracetamol groups respectively. Mean (SD) AUC PCR log10 viral load was 4.40 (0.91) in placebo and 4.64 (0.88) in paracetamol; difference was -0.24, 95% CI: -0.78 to 0.29, P = 0.36. In all participants there were no differences in symptom scores, temperature, time to resolution of illness and health status, with no interaction between randomized treatment and whether influenza was detected by PCR. CONCLUSION: Regular paracetamol had no effect on viral shedding, temperature or clinical symptoms in patients with PCR-confirmed influenza. There remains an insufficient evidence base for paracetamol use in influenza infection. CLINICAL TRIAL REGISTRATION: ACTRN12611000497909 at the Australian New Zealand Clinical Trials Registry. Twit Text FOAVip Randomized controlled trial of the effect of regular paracetamol on influenza infection ????Respirology http://www.kidney.de/pget.php?&tw=1&pmid=26638130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26638130 #FOAvip English Wikipedia <ref>{{Cite pmid|26638130}}</ref> Randomized controlled trial of the effect of regular paracetamol on influenza infection #MMPMID26638130 Jefferies S; Braithwaite I; Walker S; Weatherall M; Jennings L; Luck M; Barrett K; Siebers R; Blackmore T; Beasley R; Perrin K Respirology 2016[Feb]; 21 (2): 370-7 PMID26638130show ga BACKGROUND AND OBJECTIVE: Anti-pyretic treatment is recommended in the management of influenza infection. In animal models anti-pyretic treatment increases mortality from influenza. We investigated the effects of paracetamol on viral and clinical outcomes in adults with influenza infection. METHODS: This is a randomized, double-blind, placebo-controlled trial of adults aged 18-65 years with influenza-like illness and positive influenza rapid antigen test. Treatments were 1 g paracetamol four times a day, or matching placebo, for 5 days. Pernasal swabs were taken for influenza quantitative RT-PCR at Baseline and Days 1, 2 and 5. Temperature and symptom scores were recorded for 5-14 days or time of resolution respectively. The primary outcome variable was area under the curve (AUC) for quantitative PCR log10 viral load from Baseline to Day 5. RESULTS: A total of 80 participants were randomized: no one was lost to follow up, and one withdrew after 4 days. There were 22 and 24 participants who were influenza PCR-positive in placebo and in paracetamol groups respectively. Mean (SD) AUC PCR log10 viral load was 4.40 (0.91) in placebo and 4.64 (0.88) in paracetamol; difference was -0.24, 95% CI: -0.78 to 0.29, P = 0.36. In all participants there were no differences in symptom scores, temperature, time to resolution of illness and health status, with no interaction between randomized treatment and whether influenza was detected by PCR. CONCLUSION: Regular paracetamol had no effect on viral shedding, temperature or clinical symptoms in patients with PCR-confirmed influenza. There remains an insufficient evidence base for paracetamol use in influenza infection. CLINICAL TRIAL REGISTRATION: ACTRN12611000497909 at the Australian New Zealand Clinical Trials Registry. |Acetaminophen/*therapeutic use[MESH] |Adolescent[MESH] |Adult[MESH] |Antipyretics/*therapeutic use[MESH] |Area Under Curve[MESH] |Body Temperature/drug effects[MESH] |Double-Blind Method[MESH] |Female[MESH] |Health Status[MESH] |Humans[MESH] |Influenza, Human/*drug therapy[MESH] |Male[MESH] |Nose/virology[MESH] |Symptom Assessment[MESH] |Viral Load/*drug effects[MESH] |Virus Shedding/drug effects[MESH]Randomized controlled trial of the effect of regular paracetamol on in(epmc).pdf DeepDyve Pubget Overpricing