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10.1002/ppul.23351 http://scihub22266oqcxt.onion/10.1002/ppul.23351 26636654!7167774!26636654     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Pulmonol 2016 ; 51 (3): 225-42 Nephropedia Template TP {{tp|p=26636654|t=2016. Protracted bacterial bronchitis: The last decade and the road ahead |pdf=|usr=}}{{26636654}} gab.com Text Protracted bacterial bronchitis: The last decade and the road ahead JO: Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=26636654 #FOAvip Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bronchitis (PBB), especially in children aged <6 years. PBB is characterized by a chronic wet or productive cough without signs of an alternative cause and responds to 2 weeks of appropriate antibiotics, such as amoxicillin-clavulanate. Most children with PBB are unable to expectorate sputum. If bronchoscopy and bronchoalveolar lavage are performed, evidence of bronchitis and purulent endobronchial secretions are seen. Bronchoalveolar lavage specimens typically reveal marked neutrophil infiltration and culture large numbers of respiratory bacterial pathogens, especially Haemophilus influenzae. Although regarded as having a good prognosis, recurrences are common and if these are frequent or do not respond to antibiotic treatments of up to 4-weeks duration, the child should be investigated for other causes of chronic wet cough, such as bronchiectasis. The contribution of airway malacia and pathobiologic mechanisms of PBB remain uncertain and, other than reduced alveolar phagocytosis, evidence of systemic, or local immune deficiency is lacking. Instead, pulmonary defenses show activated innate immunity and increased gene expression of the interleukin-1beta signalling pathway. Whether these changes in local inflammatory responses are cause or effect remains to be determined. It is likely that PBB and bronchiectasis are at the opposite ends of the same disease spectrum, so children with chronic wet cough require close monitoring. Twit Text FOAVip Protracted bacterial bronchitis: The last decade and the road ahead ????Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=26636654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26636654 #FOAvip English Wikipedia <ref>{{Cite pmid|26636654}}</ref> Protracted bacterial bronchitis: The last decade and the road ahead #MMPMID26636654 Chang AB; Upham JW; Masters IB; Redding GR; Gibson PG; Marchant JM; Grimwood K Pediatr Pulmonol 2016[Mar]; 51 (3): 225-42 PMID26636654show ga Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bronchitis (PBB), especially in children aged <6 years. PBB is characterized by a chronic wet or productive cough without signs of an alternative cause and responds to 2 weeks of appropriate antibiotics, such as amoxicillin-clavulanate. Most children with PBB are unable to expectorate sputum. If bronchoscopy and bronchoalveolar lavage are performed, evidence of bronchitis and purulent endobronchial secretions are seen. Bronchoalveolar lavage specimens typically reveal marked neutrophil infiltration and culture large numbers of respiratory bacterial pathogens, especially Haemophilus influenzae. Although regarded as having a good prognosis, recurrences are common and if these are frequent or do not respond to antibiotic treatments of up to 4-weeks duration, the child should be investigated for other causes of chronic wet cough, such as bronchiectasis. The contribution of airway malacia and pathobiologic mechanisms of PBB remain uncertain and, other than reduced alveolar phagocytosis, evidence of systemic, or local immune deficiency is lacking. Instead, pulmonary defenses show activated innate immunity and increased gene expression of the interleukin-1beta signalling pathway. Whether these changes in local inflammatory responses are cause or effect remains to be determined. It is likely that PBB and bronchiectasis are at the opposite ends of the same disease spectrum, so children with chronic wet cough require close monitoring. |Adolescent[MESH] |Bacterial Infections/complications/*diagnosis[MESH] |Bronchiectasis/complications/*diagnosis[MESH] |Bronchitis/complications/*diagnosis[MESH] |Bronchoalveolar Lavage[MESH] |Bronchoscopy[MESH] |Child[MESH] |Child, Preschool[MESH] |Cough/*etiology[MESH] |Haemophilus influenzae/isolation & purification[MESH] |Humans[MESH] |Quality of Life[MESH]Protracted bacterial bronchitis: The last decade and the road ahead (epmc).pdf DeepDyve Pubget Overpricing