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10.4238/2015.December.1.15 http://scihub22266oqcxt.onion/10.4238/2015.December.1.15 26634531!ä!26634531 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26634531&cmd=llinks): Failed to open stream: HTTP request failed! 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A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections |pdf=|usr=}}{{26634531}} gab.com Text A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections JO: Genet Mol Res http://www.kidney.de/pget.php?&tw=1&pmid=26634531 #FOAvip Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing the spread of disease in public. Methods for nCoV diagnosis involve smear dyeing inspection, culture identification, and real-time PCR detection, all of which are proved highly effective. Here, we performed a meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing nCoV infection. Fifteen articles conformed to the inclusion and exclusion criteria for further meta-analysis on the basis of a wide range of publications searched from databases involving PubMed, EMBASE, Web of Science, Medline, ISI. We analyzed the stability and publication bias as well as examined the heterogeneity inspection of real-time PCR detection in contrast to smear staining and culture identification. The fixed-effect model was adopted in our meta-analysis. Our result demonstrated that the combination of real-time PCR and smear diagnostics yielded an odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.51-2.41, Z = 5.43, P < 0.05, while the combination of real-time PCR and culture identification yielded OR = 2.44, 95%CI = 1.77-3.37, Z = 5.41, P < 0.05. Therefore, we propose real-time PCR as an efficient method that offers an auxiliary support for future nCoV diagnosis. Twit Text FOAVip A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections ????Genet Mol Res http://www.kidney.de/pget.php?&tw=1&pmid=26634531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26634531 #FOAvip English Wikipedia <ref>{{Cite pmid|26634531}}</ref> A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections #MMPMID26634531 Lin C; Ye R; Xia YL Genet Mol Res 2015[Dec]; 14 (4): 15634-41 PMID26634531show ga Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing the spread of disease in public. Methods for nCoV diagnosis involve smear dyeing inspection, culture identification, and real-time PCR detection, all of which are proved highly effective. Here, we performed a meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing nCoV infection. Fifteen articles conformed to the inclusion and exclusion criteria for further meta-analysis on the basis of a wide range of publications searched from databases involving PubMed, EMBASE, Web of Science, Medline, ISI. We analyzed the stability and publication bias as well as examined the heterogeneity inspection of real-time PCR detection in contrast to smear staining and culture identification. The fixed-effect model was adopted in our meta-analysis. Our result demonstrated that the combination of real-time PCR and smear diagnostics yielded an odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.51-2.41, Z = 5.43, P < 0.05, while the combination of real-time PCR and culture identification yielded OR = 2.44, 95%CI = 1.77-3.37, Z = 5.41, P < 0.05. Therefore, we propose real-time PCR as an efficient method that offers an auxiliary support for future nCoV diagnosis. |*Real-Time Polymerase Chain Reaction/methods[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/*diagnosis/*virology[MESH] |Coronavirus/*classification/*genetics[MESH] |Humans[MESH] |Odds Ratio[MESH] |Publication Bias[MESH]A meta-analysis to evaluate the effectiveness of real-time PCR for dia(epmc).pdf DeepDyve Pubget Overpricing