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10.1016/j.prevetmed.2015.10.020 http://scihub22266oqcxt.onion/10.1016/j.prevetmed.2015.10.020 26611651!7114344!26611651     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26611651&cmd=llinks): Failed to open stream: HTTP request failed! 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Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus |pdf=|usr=}}{{26611651}} gab.com Text Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus JO: Prev Vet Med http://www.kidney.de/pget.php?&tw=1&pmid=26611651 #FOAvip Porcine epidemic diarrhea virus (PEDV) has caused severe economic losses both recently in the United States (US) and historically throughout Europe and Asia. Traditionally, analysis of the spike gene has been used to determine phylogenetic relationships between PEDV strains. We determined the complete genomes of 93 PEDV field samples from US swine and analyzed the data in conjunction with complete genome sequences available from GenBank (n=126) to determine the most variable genomic areas. Our results indicate high levels of variation within the ORF1 and spike regions while the C-terminal domains of structural genes were highly conserved. Analysis of the Receptor Binding Domains in the spike gene revealed a limited number of amino acid substitutions in US strains compared to Asian strains. Phylogenetic analysis of the complete genome sequence data revealed high rates of recombination, resulting in differing evolutionary patterns in phylogenies inferred for the spike region versus whole genomes. These finding suggest that significant genetic events outside of the spike region have contributed to the evolution of PEDV. Twit Text FOAVip Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus ????Prev Vet Med http://www.kidney.de/pget.php?&tw=1&pmid=26611651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26611651 #FOAvip English Wikipedia <ref>{{Cite pmid|26611651}}</ref> Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus #MMPMID26611651 Jarvis MC; Lam HC; Zhang Y; Wang L; Hesse RA; Hause BM; Vlasova A; Wang Q; Zhang J; Nelson MI; Murtaugh MP; Marthaler D Prev Vet Med 2016[Jan]; 123 (ä): 175-184 PMID26611651show ga Porcine epidemic diarrhea virus (PEDV) has caused severe economic losses both recently in the United States (US) and historically throughout Europe and Asia. Traditionally, analysis of the spike gene has been used to determine phylogenetic relationships between PEDV strains. We determined the complete genomes of 93 PEDV field samples from US swine and analyzed the data in conjunction with complete genome sequences available from GenBank (n=126) to determine the most variable genomic areas. Our results indicate high levels of variation within the ORF1 and spike regions while the C-terminal domains of structural genes were highly conserved. Analysis of the Receptor Binding Domains in the spike gene revealed a limited number of amino acid substitutions in US strains compared to Asian strains. Phylogenetic analysis of the complete genome sequence data revealed high rates of recombination, resulting in differing evolutionary patterns in phylogenies inferred for the spike region versus whole genomes. These finding suggest that significant genetic events outside of the spike region have contributed to the evolution of PEDV. |*Genome, Viral[MESH] |Animals[MESH] |Biological Evolution[MESH] |Coronavirus Infections/*veterinary/virology[MESH] |Diarrhea/*veterinary/virology[MESH] |Molecular Sequence Data[MESH] |Phylogeny[MESH] |Porcine epidemic diarrhea virus/*genetics[MESH] |Sequence Analysis, DNA/veterinary[MESH] |Swine[MESH] |Swine Diseases/*virology[MESH]Genomic and evolutionary inferences between American and global strain(epmc).pdf DeepDyve Pubget Overpricing