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10.1152/ajprenal.00057.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00057.2015 26582761!4888563!26582761     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2016 ; 310 (3): F230-6 Nephropedia Template TP {{tp|p=26582761|t=2016. The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics |pdf=|usr=}}{{26582761}} gab.com Text The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26582761 #FOAvip Calbindin-D28k (CBD-28k) is a calcium binding protein located in the distal convoluted tubule (DCT) and plays an important role in active calcium transport in the kidney. Loop and thiazide diuretics affect renal Ca and Mg handling: both cause Mg wasting, but have opposite effects on Ca excretion as loop diuretics increase, but thiazides decrease, Ca excretion. To understand the role of CBD-28k in renal Ca and Mg handling in response to diuretics treatment, we investigated renal Ca and Mg excretion and gene expression of DCT Ca and Mg transport molecules in wild-type (WT) and CBD-28k knockout (KO) mice. Mice were treated with chlorothiazide (CTZ; 50 mg . kg(-1) . day(-1)) or furosemide (FSM; 30 mg . kg(-1) . day(-1)) for 3 days. To avoid volume depletion, salt was supplemented in the drinking water. Urine Ca excretion was reduced in WT, but not in KO mice, by CTZ. FSM induced similar hypercalciuria in both groups. DCT Ca transport molecules, including transient receptor potential vanilloid 5 (TRPV5), TRPV6, and CBD-9k, were upregulated by CTZ and FSM in WT, but not in KO mice. Urine Mg excretion was increased and transient receptor potential subfamily M, member 6 (TRPM6) was upregulated by both CTZ and FSM in WT and KO mice. In conclusion, CBD-28k plays an important role in gene expression of DCT Ca, but not Mg, transport molecules, which may be related to its being a Ca, but not a Mg, intracellular sensor. The lack of upregulation of DCT Ca transport molecules by thiazides in the KO mice indicates that the DCT Ca transport system is critical for Ca conservation by thiazides. Twit Text FOAVip The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26582761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26582761 #FOAvip English Wikipedia <ref>{{Cite pmid|26582761}}</ref> The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics #MMPMID26582761 Lee CT; Ng HY; Lee YT; Lai LW; Lien YH Am J Physiol Renal Physiol 2016[Feb]; 310 (3): F230-6 PMID26582761show ga Calbindin-D28k (CBD-28k) is a calcium binding protein located in the distal convoluted tubule (DCT) and plays an important role in active calcium transport in the kidney. Loop and thiazide diuretics affect renal Ca and Mg handling: both cause Mg wasting, but have opposite effects on Ca excretion as loop diuretics increase, but thiazides decrease, Ca excretion. To understand the role of CBD-28k in renal Ca and Mg handling in response to diuretics treatment, we investigated renal Ca and Mg excretion and gene expression of DCT Ca and Mg transport molecules in wild-type (WT) and CBD-28k knockout (KO) mice. Mice were treated with chlorothiazide (CTZ; 50 mg . kg(-1) . day(-1)) or furosemide (FSM; 30 mg . kg(-1) . day(-1)) for 3 days. To avoid volume depletion, salt was supplemented in the drinking water. Urine Ca excretion was reduced in WT, but not in KO mice, by CTZ. FSM induced similar hypercalciuria in both groups. DCT Ca transport molecules, including transient receptor potential vanilloid 5 (TRPV5), TRPV6, and CBD-9k, were upregulated by CTZ and FSM in WT, but not in KO mice. Urine Mg excretion was increased and transient receptor potential subfamily M, member 6 (TRPM6) was upregulated by both CTZ and FSM in WT and KO mice. In conclusion, CBD-28k plays an important role in gene expression of DCT Ca, but not Mg, transport molecules, which may be related to its being a Ca, but not a Mg, intracellular sensor. The lack of upregulation of DCT Ca transport molecules by thiazides in the KO mice indicates that the DCT Ca transport system is critical for Ca conservation by thiazides. |Animals[MESH] |Blotting, Western[MESH] |Calbindin 1/deficiency/genetics/*metabolism[MESH] |Calcium Channels/genetics/metabolism[MESH] |Calcium/*metabolism/urine[MESH] |Chlorothiazide/*pharmacology[MESH] |Fluorescent Antibody Technique[MESH] |Furosemide/*pharmacology[MESH] |Gene Expression Regulation[MESH] |Genotype[MESH] |Kidney Tubules, Distal/*drug effects/metabolism[MESH] |Magnesium/*metabolism/urine[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Phenotype[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Renal Elimination/*drug effects[MESH] |S100 Calcium Binding Protein G/genetics/metabolism[MESH] |Sodium Chloride Symporter Inhibitors/*pharmacology[MESH] |Sodium Potassium Chloride Symporter Inhibitors/*pharmacology[MESH]The role of calbindin-D28k on renal calcium and magnesium handling dur(epmc).pdf DeepDyve Pubget Overpricing