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10.1016/j.apsb.2015.07.003 http://scihub22266oqcxt.onion/10.1016/j.apsb.2015.07.003 26579474/?report=reader!4629443!26579474     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharm+Sin+B 2015 ; 5 (5): 442-53 Nephropedia Template TP {{tp|p=26579474|t=2015. Insoluble drug delivery strategies: review of recent advances and business prospects |pdf=|usr=}}{{26579474}} gab.com Text Insoluble drug delivery strategies: review of recent advances and business prospects JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579474 #FOAvip The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects. Twit Text FOAVip Insoluble drug delivery strategies: review of recent advances and business prospects ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26579474 #FOAvip English Wikipedia <ref>{{Cite pmid|26579474}}</ref> Insoluble drug delivery strategies: review of recent advances and business prospects #MMPMID26579474 Kalepu S; Nekkanti V Acta Pharm Sin B 2015[Sep]; 5 (5): 442-53 PMID26579474show ga The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects. äInsoluble drug delivery strategies: review of recent advances and busi(epmc).pdf DeepDyve Pubget Overpricing