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10.1016/j.apsb.2015.05.007 http://scihub22266oqcxt.onion/10.1016/j.apsb.2015.05.007 26579469!4629436!26579469     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26579469&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Acta+Pharm+Sin+B 2015 ; 5 (5): 378-89 Nephropedia Template TP {{tp|p=26579469|t=2015. HIF-1alpha pathway: role, regulation and intervention for cancer therapy |pdf=|usr=}}{{26579469}} gab.com Text HIF-1alpha pathway: role, regulation and intervention for cancer therapy JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579469 #FOAvip Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as well as tumor resistance therapy. It was found that hypoxia (low O2 levels) is a common character in many types of solid tumors. As an adaptive response to hypoxic stress, hypoxic tumor cells activate several survival pathways to carry out their essential biological processes in different ways compared with normal cells. Recent advances in cancer biology at the cellular and molecular levels highlighted the HIF-1alpha pathway as a crucial survival pathway for which novel strategies of cancer therapy could be developed. However, targeting the HIF-1alpha pathway has been a challenging but promising progresses have been made in the past twenty years. This review summarizes the role and regulation of the HIF-1alpha in cancer, and recent therapeutic approaches targeting this important pathway. Twit Text FOAVip HIF-1alpha pathway: role, regulation and intervention for cancer therapy ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26579469 #FOAvip English Wikipedia <ref>{{Cite pmid|26579469}}</ref> HIF-1alpha pathway: role, regulation and intervention for cancer therapy #MMPMID26579469 Masoud GN; Li W Acta Pharm Sin B 2015[Sep]; 5 (5): 378-89 PMID26579469show ga Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as well as tumor resistance therapy. It was found that hypoxia (low O2 levels) is a common character in many types of solid tumors. As an adaptive response to hypoxic stress, hypoxic tumor cells activate several survival pathways to carry out their essential biological processes in different ways compared with normal cells. Recent advances in cancer biology at the cellular and molecular levels highlighted the HIF-1alpha pathway as a crucial survival pathway for which novel strategies of cancer therapy could be developed. However, targeting the HIF-1alpha pathway has been a challenging but promising progresses have been made in the past twenty years. This review summarizes the role and regulation of the HIF-1alpha in cancer, and recent therapeutic approaches targeting this important pathway. ?HIF-1alpha pathway: role, regulation and intervention for cancer thera(epmc).pdf DeepDyve Pubget Overpricing