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10.1213/XAA.0000000000000253

http://scihub22266oqcxt.onion/10.1213/XAA.0000000000000253
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26556109!ä!26556109

suck abstract from ncbi


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pmid26556109      A+A+Case+Rep 2016 ; 6 (9): 263-7
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  • Prophylactic Antibiotic Management of Surgical Patients Noted as "Allergic" to Penicillin at Two Academic Hospitals #MMPMID26556109
  • Epstein RH; Jacques PS; Wanderer JP; Bombulie MR; Agarwalla N
  • A A Case Rep 2016[May]; 6 (9): 263-7 PMID26556109show ga
  • We studied prophylactic antibiotics administered at 2 academic medical centers during a 6-year period where a cephalosporin was indicated but an "allergy" to penicillin was noted. Another drug (typically vancomycin or clindamycin) was substituted approximately 80% of the time; this occurred frequently even when symptoms unrelated to acute hypersensitivity were listed. In >50% of cases, the reaction was either omitted or vague (e.g., simply "rash"). Given the estimated 1% cross-reactivity between penicillins and cephalosporins with similar R1 side chains, many of these patients could have received either the prescribed cephalosporin or another cephalosporin with a different R1 side chain.
  • |Anti-Bacterial Agents/*administration & dosage[MESH]
  • |Antibiotic Prophylaxis/*methods[MESH]
  • |Cephalosporins/administration & dosage[MESH]
  • |Cross Reactions[MESH]
  • |Drug Hypersensitivity/epidemiology/*prevention & control[MESH]
  • |Electronic Health Records[MESH]
  • |Humans[MESH]
  • |Penicillins/*adverse effects[MESH]


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