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10.1186/s40478-015-0245-8 http://scihub22266oqcxt.onion/10.1186/s40478-015-0245-8 26531194/?report=reader!4632469!26531194     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2015 ; 3 (ä): 67 Nephropedia Template TP {{tp|p=26531194|t=2015. Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity |pdf=|usr=}}{{26531194}} gab.com Text Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26531194 #FOAvip Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with septic delirium. Hippocampal dysfunction was further investigated in an animal model for sepsis using lipopolysaccharide (LPS) injections to induce endotoxemia in rats, followed by electrophysiological recordings in brain slices. Endotoxemia induced a deficit in long term potentiation which was completely reversed by apamin, a blocker of small conductance calcium-activated potassium (SK) channels, and partly restored by treatment with physostigmine (eserine), an acetylcholinesterase inhibitor, or TBPB, a selective M1 muscarinic acetylcholine receptor agonist. These results suggest a novel role for SK channels in the etiology of endotoxemia and explain why boosting cholinergic function restores deficits in synaptic plasticity. Drugs which enhance cholinergic or M1 activity in the brain may prove beneficial in treatment of septic delirium in the intensive care unit. Twit Text FOAVip Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26531194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26531194 #FOAvip English Wikipedia <ref>{{Cite pmid|26531194}}</ref> Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity #MMPMID26531194 Zivkovic AR; Sedlaczek O; von Haken R; Schmidt K; Brenner T; Weigand MA; Bading H; Bengtson CP; Hofer S Acta Neuropathol Commun 2015[Nov]; 3 (ä): 67 PMID26531194show ga Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with septic delirium. Hippocampal dysfunction was further investigated in an animal model for sepsis using lipopolysaccharide (LPS) injections to induce endotoxemia in rats, followed by electrophysiological recordings in brain slices. Endotoxemia induced a deficit in long term potentiation which was completely reversed by apamin, a blocker of small conductance calcium-activated potassium (SK) channels, and partly restored by treatment with physostigmine (eserine), an acetylcholinesterase inhibitor, or TBPB, a selective M1 muscarinic acetylcholine receptor agonist. These results suggest a novel role for SK channels in the etiology of endotoxemia and explain why boosting cholinergic function restores deficits in synaptic plasticity. Drugs which enhance cholinergic or M1 activity in the brain may prove beneficial in treatment of septic delirium in the intensive care unit. |Analysis of Variance[MESH] |Animals[MESH] |Apamin/pharmacology[MESH] |Area Under Curve[MESH] |Biophysics[MESH] |Cholinergic Agents/pharmacology[MESH] |Diffusion Magnetic Resonance Imaging[MESH] |Disease Models, Animal[MESH] |Electric Stimulation[MESH] |Hippocampus/*cytology/drug effects[MESH] |In Vitro Techniques[MESH] |Lipopolysaccharides/*pharmacology[MESH] |Long-Term Potentiation/*drug effects/physiology[MESH] |Neuronal Plasticity/*drug effects[MESH] |Neurons/*drug effects[MESH] |Patch-Clamp Techniques[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Receptor, Muscarinic M1/*metabolism[MESH]Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic (epmc).pdf DeepDyve Pubget Overpricing