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10.1016/j.etap.2015.09.020 http://scihub22266oqcxt.onion/10.1016/j.etap.2015.09.020 26509733!ä!26509733 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Environ+Toxicol+Pharmacol 2015 ; 40 (3): 924-30 Nephropedia Template TP {{tp|p=26509733|t=2015. The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology |pdf=|usr=}}{{26509733}} gab.com Text The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology JO: Environ Toxicol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26509733 #FOAvip Obese individuals show increased susceptibility to infection, low vaccine efficacy, and worse pathophysiology. However, it is unclear how obesity affects these events. The aim of this study was to investigate the effect of obesity-triggered chronic inflammation on immune cells after influenza virus infection. Control and lipopolysaccharide mice, in which an osmotic pump continually released Tween saline or lipopolysaccharide, were prepared and 3 weeks later were infected with pandemic H1N1 2009 influenza A virus. In lipopolysaccharide mice, we found a reduction in macrophage activation markers in the steady state, and reduced production of pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, in restimulated peritoneal macrophages. Interestingly, lipopolysaccharide-triggered chronic inflammation exacerbated the severity of pathological symptoms in the lungs after challenge with influenza virus. Taken together, the increased severity of virus-induced symptoms in obese individuals with chronic inflammation may be, at least partially, caused by macrophage dysfunction. Twit Text FOAVip The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology ????Environ Toxicol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26509733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26509733 #FOAvip English Wikipedia <ref>{{Cite pmid|26509733}}</ref> The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology #MMPMID26509733 Ahn SY; Sohn SH; Lee SY; Park HL; Park YW; Kim H; Nam JH Environ Toxicol Pharmacol 2015[Nov]; 40 (3): 924-30 PMID26509733show ga Obese individuals show increased susceptibility to infection, low vaccine efficacy, and worse pathophysiology. However, it is unclear how obesity affects these events. The aim of this study was to investigate the effect of obesity-triggered chronic inflammation on immune cells after influenza virus infection. Control and lipopolysaccharide mice, in which an osmotic pump continually released Tween saline or lipopolysaccharide, were prepared and 3 weeks later were infected with pandemic H1N1 2009 influenza A virus. In lipopolysaccharide mice, we found a reduction in macrophage activation markers in the steady state, and reduced production of pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, in restimulated peritoneal macrophages. Interestingly, lipopolysaccharide-triggered chronic inflammation exacerbated the severity of pathological symptoms in the lungs after challenge with influenza virus. Taken together, the increased severity of virus-induced symptoms in obese individuals with chronic inflammation may be, at least partially, caused by macrophage dysfunction. |Animals[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Gene Expression Regulation/drug effects[MESH] |Influenza A Virus, H1N1 Subtype/*immunology[MESH] |Influenza Vaccines/immunology[MESH] |Lipopolysaccharides/*adverse effects[MESH] |Macrophage Activation[MESH] |Macrophages, Peritoneal/*drug effects/pathology[MESH] |Mice[MESH] |Obesity/chemically induced/*complications/immunology[MESH]The effect of lipopolysaccharide-induced obesity and its chronic infla(epmc).pdf DeepDyve Pubget Overpricing