Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.micinf.2015.10.003 http://scihub22266oqcxt.onion/10.1016/j.micinf.2015.10.003 26482504!ä!26482504 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbes+Infect 2016 ; 18 (2): 118-27 Nephropedia Template TP {{tp|p=26482504|t=2016. Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264 7 cells |pdf=|usr=}}{{26482504}} gab.com Text Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264 7 cells JO: Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=26482504 #FOAvip Streptococcus pyogenes produces molecules that inhibit the function of human immune system, thus allowing the pathogen to grow and spread in tissues. It is known that S. pyogenes CAMP factor increases erythrocytosis induced by Staphylococcus aureus beta-hemolysin. However, the effects of CAMP factor for immune cells are unclear. In this study, we investigated the effects of CAMP factor to macrophages. Western blotting analysis demonstrated that all examined strains expressed CAMP factor protein. In the presence of calcium or magnesium ion, CAMP factor was significantly released in the supernatant. In addition, both culture supernatant from S. pyogenes strain SSI-9 and recombinant CAMP factor dose-dependently induced vacuolation in RAW 264.7 cells, but the culture supernatant from Deltacfa isogenic mutant strain did not. CAMP factor formed oligomers in RAW 264.7 cells in a time-dependent manner. CAMP factor suppressed cell proliferation via G2 phase cell cycle arrest without inducing cell death. Furthermore, CAMP factor reduced the uptake of S. pyogenes and phagocytic activity indicator by RAW 264.7 cells. These results suggest that CAMP factor works as a macrophage dysfunction factor. Therefore, we conclude that CAMP factor allows S. pyogenes to escape the host immune system, and contribute to the spread of streptococcal infection. Twit Text FOAVip Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264 7 cells ????Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=26482504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26482504 #FOAvip English Wikipedia <ref>{{Cite pmid|26482504}}</ref> Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264 7 cells #MMPMID26482504 Kurosawa M; Oda M; Domon H; Saitoh I; Hayasaki H; Terao Y Microbes Infect 2016[Feb]; 18 (2): 118-27 PMID26482504show ga Streptococcus pyogenes produces molecules that inhibit the function of human immune system, thus allowing the pathogen to grow and spread in tissues. It is known that S. pyogenes CAMP factor increases erythrocytosis induced by Staphylococcus aureus beta-hemolysin. However, the effects of CAMP factor for immune cells are unclear. In this study, we investigated the effects of CAMP factor to macrophages. Western blotting analysis demonstrated that all examined strains expressed CAMP factor protein. In the presence of calcium or magnesium ion, CAMP factor was significantly released in the supernatant. In addition, both culture supernatant from S. pyogenes strain SSI-9 and recombinant CAMP factor dose-dependently induced vacuolation in RAW 264.7 cells, but the culture supernatant from Deltacfa isogenic mutant strain did not. CAMP factor formed oligomers in RAW 264.7 cells in a time-dependent manner. CAMP factor suppressed cell proliferation via G2 phase cell cycle arrest without inducing cell death. Furthermore, CAMP factor reduced the uptake of S. pyogenes and phagocytic activity indicator by RAW 264.7 cells. These results suggest that CAMP factor works as a macrophage dysfunction factor. Therefore, we conclude that CAMP factor allows S. pyogenes to escape the host immune system, and contribute to the spread of streptococcal infection. |*Host-Pathogen Interactions[MESH] |*Immune Evasion[MESH] |Animals[MESH] |Bacterial Proteins/*metabolism[MESH] |Cell Proliferation/drug effects[MESH] |Hemolysin Proteins/*metabolism[MESH] |Macrophages/*immunology/*microbiology[MESH] |Mice[MESH] |Phagocytosis/*drug effects[MESH] |RAW 264.7 Cells[MESH]Streptococcus pyogenes CAMP factor attenuates phagocytic activity of R(epmc).pdf DeepDyve Pubget Overpricing