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10.1093/femsle/fnv192 http://scihub22266oqcxt.onion/10.1093/femsle/fnv192 26459885!ä!26459885 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEMS+Microbiol+Lett 2015 ; 362 (23): fnv192 Nephropedia Template TP {{tp|p=26459885|t=2015. Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs) |pdf=|usr=}}{{26459885}} gab.com Text Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs) JO: FEMS Microbiol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26459885 #FOAvip Neutrophil extracellular trap (NET) formation is described as a tool of the innate host defence to fight against invading pathogens. Fibre-like DNA structures associated with proteins such as histones, cell-specific enzymes and antimicrobial peptides are released, thereby entrapping invading pathogens. It has been reported that several bacteria are able to degrade NETs by nucleases and thus evade the NET-mediated entrapment. Here we studied the ability of three different Yersinia serotypes to induce and degrade NETs. We found that the common Yersinia enterocolitica serotypes O:3, O:8 and O:9 were able to induce NETs in human blood-derived neutrophils during the first hour of co-incubation. At later time points, the NET amount was reduced, suggesting that degradation of NETs has occurred. This was confirmed by NET degradation assays with phorbol-myristate-acetate-pre-stimulated neutrophils. In addition, we found that the Yersinia supernatants were able to degrade purified plasmid DNA. The absence of Ca(2+) and Mg(2+) ions, but not that of a protease inhibitor cocktail, completely abolished NET degradation. We therefore postulate that Y. enterocolitica produces Ca(2+)/Mg(2+)-dependent NET-degrading nucleases as shown for some Gram-positive pathogens. Twit Text FOAVip Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs) ????FEMS Microbiol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26459885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459885 #FOAvip English Wikipedia <ref>{{Cite pmid|26459885}}</ref> Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs) #MMPMID26459885 Mollerherm H; Neumann A; Schilcher K; Blodkamp S; Zeitouni NE; Dersch P; Luthje P; Naim HY; Zinkernagel AS; von Kockritz-Blickwede M FEMS Microbiol Lett 2015[Dec]; 362 (23): fnv192 PMID26459885show ga Neutrophil extracellular trap (NET) formation is described as a tool of the innate host defence to fight against invading pathogens. Fibre-like DNA structures associated with proteins such as histones, cell-specific enzymes and antimicrobial peptides are released, thereby entrapping invading pathogens. It has been reported that several bacteria are able to degrade NETs by nucleases and thus evade the NET-mediated entrapment. Here we studied the ability of three different Yersinia serotypes to induce and degrade NETs. We found that the common Yersinia enterocolitica serotypes O:3, O:8 and O:9 were able to induce NETs in human blood-derived neutrophils during the first hour of co-incubation. At later time points, the NET amount was reduced, suggesting that degradation of NETs has occurred. This was confirmed by NET degradation assays with phorbol-myristate-acetate-pre-stimulated neutrophils. In addition, we found that the Yersinia supernatants were able to degrade purified plasmid DNA. The absence of Ca(2+) and Mg(2+) ions, but not that of a protease inhibitor cocktail, completely abolished NET degradation. We therefore postulate that Y. enterocolitica produces Ca(2+)/Mg(2+)-dependent NET-degrading nucleases as shown for some Gram-positive pathogens. |Amino Acid Sequence[MESH] |Bacterial Proteins/chemistry/metabolism[MESH] |Calcium/metabolism[MESH] |Endodeoxyribonucleases/chemistry/metabolism[MESH] |Extracellular Traps/immunology/*metabolism/microbiology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Magnesium/metabolism[MESH] |Membrane Proteins/chemistry/metabolism[MESH] |Neutrophils/immunology/metabolism[MESH] |Sequence Alignment[MESH] |Serogroup[MESH]Yersinia enterocolitica-mediated degradation of neutrophil extracellul(epmc).pdf DeepDyve Pubget Overpricing