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10.3109/17453674.2015.1094613

http://scihub22266oqcxt.onion/10.3109/17453674.2015.1094613
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26414972/?report=reader!4940594!26414972
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suck abstract from ncbi


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pmid26414972      Acta+Orthop 2016 ; 87 (1): 60-6
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  • Treatment of prosthetic joint infections due to Propionibacterium Similar results in 60 patients treated with and without rifampicin #MMPMID26414972
  • Jacobs AM; Van Hooff ML; Meis JF; Vos F; Goosen JH
  • Acta Orthop 2016[Feb]; 87 (1): 60-6 PMID26414972show ga
  • BACKGROUND AND PURPOSE: Currently, Propionibacterium is frequently recognized as a causative microorganism of prosthetic joint infection (PJI). We assessed treatment success at 1- and 2-year follow-up after treatment of Propionibacterium-associated PJI of the shoulder, hip, and knee. Furthermore, we attempted to determine whether postoperative treatment with rifampicin is favorable. PATIENTS AND METHODS: We conducted a retrospective cohort study in which we included patients with a primary or revision joint arthroplasty of the shoulder, hip, or knee who were diagnosed with a Propionibacterium-associated PJI between November 2008 and February 2013 and who had been followed up for at least 1 year. RESULTS: We identified 60 patients with a Propionibacterium-associated PJI with a median duration of 21 (0.1-49) months until the occurrence of treatment failure. 39 patients received rifampicin combination therapy, with a success rate of 93% (95% CI: 83-97) after 1 year and 86% (CI: 71-93) after 2 years. The success rate was similar in patients who were treated with rifampicin and those who were not. INTERPRETATION: Propionibacterium-associated PJI treated with surgery in combination with long-term antibiotic administration had a successful outcome at 1- and 2-year follow-up irrespective of whether the patient was treated with rifampicin. Prospective studies are needed to determine whether the use of rifampicin is beneficial in the treatment of Propionibacterium-associated PJI.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Analysis of Variance[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Gram-Positive Bacterial Infections/diagnosis/*drug therapy[MESH]
  • |Hip Prosthesis/adverse effects[MESH]
  • |Humans[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Knee Prosthesis/adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Netherlands[MESH]
  • |Propionibacterium/*drug effects/isolation & purification[MESH]
  • |Prosthesis Failure[MESH]
  • |Prosthesis-Related Infections/*drug therapy/*microbiology/surgery[MESH]
  • |Reference Values[MESH]
  • |Reoperation/methods[MESH]
  • |Retrospective Studies[MESH]
  • |Rifampin/*therapeutic use[MESH]
  • |Risk Assessment[MESH]
  • |Severity of Illness Index[MESH]


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