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10.1007/s40472-015-0054-9

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26301174!4541698!26301174
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suck abstract from ncbi

pmid26301174      Curr+Transplant+Rep 2015 ; 2 (2): 176-183
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  • Monocyte-Derived Suppressor Cells in Transplantation #MMPMID26301174
  • Ochando J; Conde P; Bronte V
  • Curr Transplant Rep 2015[]; 2 (2): 176-183 PMID26301174show ga
  • Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and granulocytic (G-MDSC) origin. A more recent nomenclature proposes the term "suppressive monocyte derived cells" (suppressive MCs) to define CSF1/CSF2-dependent mouse suppressor cells that develop from common monocyte progenitors (cMoPs) after birth. Here, we review the literature about monocytic-derived cells with demonstrated suppressor function in vitro and in vivo within the context of solid organ transplantation.
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