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10.1093/rheumatology/kev286

http://scihub22266oqcxt.onion/10.1093/rheumatology/kev286
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26297628!ä!26297628

suck abstract from ncbi


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pmid26297628      Rheumatology+(Oxford) 2016 ; 55 (1): 71-9
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  • Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort #MMPMID26297628
  • Schirmer JH; Wright MN; Vonthein R; Herrmann K; Nolle B; Both M; Henes FO; Arlt A; Gross WL; Schinke S; Reinhold-Keller E; Moosig F; Holle JU
  • Rheumatology (Oxford) 2016[Jan]; 55 (1): 71-9 PMID26297628show ga
  • OBJECTIVE: To evaluate the clinical presentation and long-term outcome of a vasculitis centre cohort of patients with microscopic polyangiitis (MPA) with respect to organ manifestations, treatment, chronic damage and mortality. METHODS: We performed a retrospective chart review at our vasculitis referral centre. MPA patients admitted between 1991 and 2013 classified by a modified European Medicines Agency algorithm were diagnosed and treated according to a standardized interdisciplinary approach. RESULTS: Comprehensive data from standardized interdisciplinary workups was available for 144 patients (median follow-up 72 months). The overall standardized mortality ratio was 1.40 (95% CI 0.91, 2.07; P = 0.13). We observed a higher mortality [hazard ratio (HR) 4.04 (95% CI 1.21, 13.45), P = 0.02] in 17 patients with MPA-associated fibrosing interstitial lung disease (ILD) and 56 patients with peripheral nervous system involvement [HR 5.26 (95% CI 1.10, 25.14), P = 0.04] at disease onset. One hundred and fifteen patients (79.9%) responded to the initial treatment. Sixty-one (42.3%) achieved complete remission and 54 (37.5%) achieved partial remission. Twenty (13.9%) showed a refractory disease course. CONCLUSION: MPA patients at our tertiary rheumatology referral centre seemed to have a less severe phenotype resulting in a less severe disease course and better outcome than reported in other cohorts. Fibrosing ILD was significantly associated with mortality in this cohort.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Germany/epidemiology[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |Microscopic Polyangiitis/*diagnosis/drug therapy/epidemiology[MESH]
  • |Middle Aged[MESH]
  • |Remission Induction/methods[MESH]
  • |Retrospective Studies[MESH]
  • |Survival Rate/trends[MESH]
  • |Time Factors[MESH]


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