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10.1002/jmv.24359 http://scihub22266oqcxt.onion/10.1002/jmv.24359 26287378!7166822!26287378     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2016 ; 88 (3): 541-9 Nephropedia Template TP {{tp|p=26287378|t=2016. Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis |pdf=|usr=}}{{26287378}} gab.com Text Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=26287378 #FOAvip Secondary hemophagocytic lymphohistiocytosis (SHLH) is a potentially fatal hyperinflammatory syndrome with a heterogeneous etiology and has nonspecific clinical and laboratory findings. The diagnosis and treatment of adult SHLH is challenging because the etiology of the disease is difficult to identify, and the majority of reported cases are pediatric patients. The aim of this study was to describe the etiology, clinical characteristics, and outcomes of adult SHLH. Fifty-four adult patients who fulfilled the criteria of SHLH were enrolled in the study. Viral etiology, blood biomarkers, and clinical manifestations of SHLH were analyzed in these patients. Twenty-four SHLH patients had viraemia, whereas 30 SHLH patients were secondary to other diseases. Epstein-Barr virus (EBV) was the most common virus that associated SHLH among all viruses studied. Severe SHLH patients with EBV-viraemia presented significantly high levels of ferritin, lactate dehydrogenase, aspartate transaminase (AST), and alanine transaminase (ALT). Positively relationships existed between EBV DNA titers and levels of AST and ALT (P < 0.05). The prognosis of SHLH patients with EBV viraemia was worse than that of non-EBV SHLH and non-viral SHLH. Our data reveal that EBV is the major pathogen in virus-associated SHLH, and EBV load influence disease development in SHLH patients with EBV infection that prognosis is worse than other viruses associated SHLH. Twit Text FOAVip Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=26287378 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26287378 #FOAvip English Wikipedia <ref>{{Cite pmid|26287378}}</ref> Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis #MMPMID26287378 Chen J; Wang X; He P; Li Y; Si M; Fan Z; Chang X; Xie Q; Jiao X J Med Virol 2016[Mar]; 88 (3): 541-9 PMID26287378show ga Secondary hemophagocytic lymphohistiocytosis (SHLH) is a potentially fatal hyperinflammatory syndrome with a heterogeneous etiology and has nonspecific clinical and laboratory findings. The diagnosis and treatment of adult SHLH is challenging because the etiology of the disease is difficult to identify, and the majority of reported cases are pediatric patients. The aim of this study was to describe the etiology, clinical characteristics, and outcomes of adult SHLH. Fifty-four adult patients who fulfilled the criteria of SHLH were enrolled in the study. Viral etiology, blood biomarkers, and clinical manifestations of SHLH were analyzed in these patients. Twenty-four SHLH patients had viraemia, whereas 30 SHLH patients were secondary to other diseases. Epstein-Barr virus (EBV) was the most common virus that associated SHLH among all viruses studied. Severe SHLH patients with EBV-viraemia presented significantly high levels of ferritin, lactate dehydrogenase, aspartate transaminase (AST), and alanine transaminase (ALT). Positively relationships existed between EBV DNA titers and levels of AST and ALT (P < 0.05). The prognosis of SHLH patients with EBV viraemia was worse than that of non-EBV SHLH and non-viral SHLH. Our data reveal that EBV is the major pathogen in virus-associated SHLH, and EBV load influence disease development in SHLH patients with EBV infection that prognosis is worse than other viruses associated SHLH. |Adult[MESH] |Aged[MESH] |Alanine Transaminase/blood[MESH] |Aspartate Aminotransferases/blood[MESH] |Biomarkers/blood[MESH] |DNA, Viral/*blood[MESH] |Epstein-Barr Virus Infections/blood/*virology[MESH] |Female[MESH] |Ferritins[MESH] |Herpesvirus 4, Human/*isolation & purification[MESH] |Humans[MESH] |L-Lactate Dehydrogenase/blood[MESH] |Lymphohistiocytosis, Hemophagocytic/complications/*diagnosis/physiopathology/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |Viremia[MESH]Viral etiology, clinical and laboratory features of adult hemophagocyt(epmc).pdf DeepDyve Pubget Overpricing