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10.1021/acs.jnatprod.5b00348 http://scihub22266oqcxt.onion/10.1021/acs.jnatprod.5b00348 26280594!ä!26280594 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Nat+Prod 2015 ; 78 (8): 2110-5 Nephropedia Template TP {{tp|p=26280594|t=2015. Upregulation of Collagen Expression via PPARbeta/delta Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza |pdf=|usr=}}{{26280594}} gab.com Text Upregulation of Collagen Expression via PPARbeta/delta Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza JO: J Nat Prod http://www.kidney.de/pget.php?&tw=1&pmid=26280594 #FOAvip This study investigated the agonistic activity of magnesium lithospermate B (1), isolated from Salvia miltiorrhiza, on peroxisome proliferator-activated receptor (PPARbeta/delta) and the expressions of collagen genes (COL1A1 and COL3A1) and transforming growth factor-beta1 (TGF-beta1) in models of skin aging. The action of compound 1 as a PPARbeta/delta agonist was determined by reporter gene assay, immunostaining, and Western blotting. To determine the antiaging effects of compound 1 on skin, aged Sprague-Dawley rat skin and ultraviolet B (UVB)-irradiated human skin fibroblasts were used. The results show that 1 presented a marked enhancement of both nuclear protein levels and activity of PPARbeta/delta in fibroblasts. In addition, 1 prevented downregulation of PPARbeta/delta activity in aged rat skin and UVB-induced fibroblasts. Furthermore, 1 increased the expressions of COL1A1, COL3A1, and TGF-beta1 in vivo and in a cell culture system. Therefore, the present study shows that compound 1 prevents collagen degradation in aged rat skin and UVB-exposed fibroblasts through PPARbeta/delta activation. The therapeutic and cosmetic applications of compound 1 need further investigation. Twit Text FOAVip Upregulation of Collagen Expression via PPARbeta/delta Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza ????J Nat Prod http://www.kidney.de/pget.php?&tw=1&pmid=26280594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26280594 #FOAvip English Wikipedia <ref>{{Cite pmid|26280594}}</ref> Upregulation of Collagen Expression via PPARbeta/delta Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza #MMPMID26280594 Jung YR; Lee EK; Kim DH; Park CH; Park MH; Jeong HO; Yokozawa T; Tanaka T; Im DS; Kim ND; Yu BP; Mo SH; Chung HY J Nat Prod 2015[Aug]; 78 (8): 2110-5 PMID26280594show ga This study investigated the agonistic activity of magnesium lithospermate B (1), isolated from Salvia miltiorrhiza, on peroxisome proliferator-activated receptor (PPARbeta/delta) and the expressions of collagen genes (COL1A1 and COL3A1) and transforming growth factor-beta1 (TGF-beta1) in models of skin aging. The action of compound 1 as a PPARbeta/delta agonist was determined by reporter gene assay, immunostaining, and Western blotting. To determine the antiaging effects of compound 1 on skin, aged Sprague-Dawley rat skin and ultraviolet B (UVB)-irradiated human skin fibroblasts were used. The results show that 1 presented a marked enhancement of both nuclear protein levels and activity of PPARbeta/delta in fibroblasts. In addition, 1 prevented downregulation of PPARbeta/delta activity in aged rat skin and UVB-induced fibroblasts. Furthermore, 1 increased the expressions of COL1A1, COL3A1, and TGF-beta1 in vivo and in a cell culture system. Therefore, the present study shows that compound 1 prevents collagen degradation in aged rat skin and UVB-exposed fibroblasts through PPARbeta/delta activation. The therapeutic and cosmetic applications of compound 1 need further investigation. |Aged[MESH] |Animals[MESH] |Collagen/*metabolism[MESH] |Drugs, Chinese Herbal/chemistry/metabolism[MESH] |Fibroblasts/drug effects[MESH] |Humans[MESH] |Magnesium/metabolism[MESH] |Male[MESH] |Molecular Structure[MESH] |NF-kappa B/metabolism[MESH] |PPAR delta/*metabolism[MESH] |PPAR-beta/*metabolism[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Salvia miltiorrhiza/*chemistry[MESH] |Skin/*drug effects[MESH] |Transcriptional Activation[MESH]Upregulation of Collagen Expression via PPARbeta/delta Activation in A(epmc).pdf DeepDyve Pubget Overpricing