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10.1038/icb.2015.81 http://scihub22266oqcxt.onion/10.1038/icb.2015.81 26272554!ä!26272554 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Cell+Biol 2016 ; 94 (2): 169-76 Nephropedia Template TP {{tp|p=26272554|t=2016. Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam(2)Cys |pdf=|usr=}}{{26272554}} gab.com Text Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam(2)Cys JO: Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26272554 #FOAvip We have previously shown that intranasal administration of the Toll-like receptor-2 agonist, S-(2,3-bis(palmitoyloxy)propyl) cysteine (Pam2Cys), provides immediate and antigen independent protection against challenge with influenza virus. Here we characterize the cellular pulmonary environments of mice which had either been treated with Pam2Cys or placebo and then challenged with influenza virus. We show that Pam2Cys treatment results in the influx of innate immune cells into the lungs and that depletion of phagocytic cells from this influx using clodronate-loaded liposomes caused a reduction in the number of interstitial macrophages and monocytes. This resulted in abolition of the protective effect indicating the importance of this cellular subset in Pam2Cys-mediated protection. Twit Text FOAVip Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam(2)Cys ????Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26272554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26272554 #FOAvip English Wikipedia <ref>{{Cite pmid|26272554}}</ref> Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam(2)Cys #MMPMID26272554 Mifsud EJ; Tan AC; Reading PC; Jackson DC Immunol Cell Biol 2016[Feb]; 94 (2): 169-76 PMID26272554show ga We have previously shown that intranasal administration of the Toll-like receptor-2 agonist, S-(2,3-bis(palmitoyloxy)propyl) cysteine (Pam2Cys), provides immediate and antigen independent protection against challenge with influenza virus. Here we characterize the cellular pulmonary environments of mice which had either been treated with Pam2Cys or placebo and then challenged with influenza virus. We show that Pam2Cys treatment results in the influx of innate immune cells into the lungs and that depletion of phagocytic cells from this influx using clodronate-loaded liposomes caused a reduction in the number of interstitial macrophages and monocytes. This resulted in abolition of the protective effect indicating the importance of this cellular subset in Pam2Cys-mediated protection. |Administration, Intranasal[MESH] |Animals[MESH] |Cell Movement/drug effects[MESH] |Clodronic Acid/administration & dosage[MESH] |Female[MESH] |Immunity, Innate/drug effects[MESH] |Influenza A Virus, H1N1 Subtype/*immunology[MESH] |Lipopeptides/*administration & dosage/pharmacology[MESH] |Lung/*drug effects/immunology/virology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Orthomyxoviridae Infections/*drug therapy/immunology[MESH]Mapping the pulmonary environment of animals protected from virulent H(epmc).pdf DeepDyve Pubget Overpricing