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10.1097/ANC.0000000000000191 http://scihub22266oqcxt.onion/10.1097/ANC.0000000000000191 26240939/?report=reader!4583334!26240939     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Neonatal+Care 2015 ; 15 (5): 314-23; quiz E1-2 Nephropedia Template TP {{tp|p=26240939|t=2015. Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Signaling System |pdf=|usr=}}{{26240939}} gab.com Text Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Signaling System JO: Adv Neonatal Care http://www.kidney.de/pget.php?&tw=1&pmid=26240939 #FOAvip BACKGROUND: Over the past decades, advances in neonatal care have led to substantial increases in survival among preterm infants. With these gains, recent concerns have focused on increases in neurodevelopment morbidity related to the interplay between stressful early life experiences and the immature neuroimmune systems. This interplay between these complex mechanisms is often described as the brain-gut signaling system. The role of the gut microbiome and the brain-gut signaling system have been found to be remarkably related to both short- and long-term stress and health. Recent evidence supports that microbial species, ligands, and/or products within the developing intestine play a key role in early programming of the central nervous system and regulation of the intestinal innate immunity. PURPOSE: The purpose of this state-of-the-science review is to explore the supporting evidence demonstrating the importance of the brain-gut-microbiota axis in regulation of early life experience. We also discuss the role of gut microbiome in modulating stress and pain responses in high-risk infants. A conceptual framework has been developed to illustrate the regulation mechanisms involved in early life experience. CONCLUSIONS: The science in this area is just beginning to be uncovered; having a fundamental understanding of these relationships will be important as new discoveries continue to change our thinking, leading potentially to changes in practice and targeted interventions. Twit Text FOAVip Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Signaling System ????Adv Neonatal Care http://www.kidney.de/pget.php?&tw=1&pmid=26240939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26240939 #FOAvip English Wikipedia <ref>{{Cite pmid|26240939}}</ref> Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Signaling System #MMPMID26240939 Cong X; Henderson WA; Graf J; McGrath JM Adv Neonatal Care 2015[Oct]; 15 (5): 314-23; quiz E1-2 PMID26240939show ga BACKGROUND: Over the past decades, advances in neonatal care have led to substantial increases in survival among preterm infants. With these gains, recent concerns have focused on increases in neurodevelopment morbidity related to the interplay between stressful early life experiences and the immature neuroimmune systems. This interplay between these complex mechanisms is often described as the brain-gut signaling system. The role of the gut microbiome and the brain-gut signaling system have been found to be remarkably related to both short- and long-term stress and health. Recent evidence supports that microbial species, ligands, and/or products within the developing intestine play a key role in early programming of the central nervous system and regulation of the intestinal innate immunity. PURPOSE: The purpose of this state-of-the-science review is to explore the supporting evidence demonstrating the importance of the brain-gut-microbiota axis in regulation of early life experience. We also discuss the role of gut microbiome in modulating stress and pain responses in high-risk infants. A conceptual framework has been developed to illustrate the regulation mechanisms involved in early life experience. CONCLUSIONS: The science in this area is just beginning to be uncovered; having a fundamental understanding of these relationships will be important as new discoveries continue to change our thinking, leading potentially to changes in practice and targeted interventions. |*Neuroimmunomodulation[MESH] |Brain/*immunology/metabolism[MESH] |Gastrointestinal Microbiome/*immunology[MESH] |Gastrointestinal Tract/*immunology/metabolism/microbiology[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Infant, Premature[MESH] |Maternal Deprivation[MESH] |Pain/*immunology/metabolism/psychology[MESH] |Stress, Physiological/*immunology[MESH]Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Sig(epmc).pdf DeepDyve Pubget Overpricing