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10.1016/j.arr.2015.07.007 http://scihub22266oqcxt.onion/10.1016/j.arr.2015.07.007 26226329/?report=reader!4661124!26226329     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ageing+Res+Rev 2015 ; 24 (Pt B): 111-25 Nephropedia Template TP {{tp|p=26226329|t=2015. ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target |pdf=|usr=}}{{26226329}} gab.com Text ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target JO: Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=26226329 #FOAvip The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging. The KATP channel also helps regulate the neurovascular unit. Most brain cell types express SUR2, including neurons, astrocytes, oligodendrocytes, microglia, vascular smooth muscle, pericytes, and endothelial cells. Thus it is not surprising that ABCC9 gene variants are associated with risk for human brain diseases. For example, Cantu syndrome is a result of ABCC9 mutations; we discuss neurologic manifestations of this genetic syndrome. More common brain disorders linked to ABCC9 gene variants include hippocampal sclerosis of aging (HS-Aging), sleep disorders, and depression. HS-Aging is a prevalent neurological disease with pathologic features of both neurodegenerative (aberrant TDP-43) and cerebrovascular (arteriolosclerosis) disease. As to potential therapeutic intervention, the human pharmacopeia features both SUR2 agonists and antagonists, so ABCC9/SUR2 may provide a "druggable target", relevant perhaps to both HS-Aging and Alzheimer's disease. We conclude that more work is required to better understand the roles of ABCC9/SUR2 in the human brain during health and disease conditions. Twit Text FOAVip ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target ????Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=26226329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26226329 #FOAvip English Wikipedia <ref>{{Cite pmid|26226329}}</ref> ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target #MMPMID26226329 Nelson PT; Jicha GA; Wang WX; Ighodaro E; Artiushin S; Nichols CG; Fardo DW Ageing Res Rev 2015[Nov]; 24 (Pt B): 111-25 PMID26226329show ga The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging. The KATP channel also helps regulate the neurovascular unit. Most brain cell types express SUR2, including neurons, astrocytes, oligodendrocytes, microglia, vascular smooth muscle, pericytes, and endothelial cells. Thus it is not surprising that ABCC9 gene variants are associated with risk for human brain diseases. For example, Cantu syndrome is a result of ABCC9 mutations; we discuss neurologic manifestations of this genetic syndrome. More common brain disorders linked to ABCC9 gene variants include hippocampal sclerosis of aging (HS-Aging), sleep disorders, and depression. HS-Aging is a prevalent neurological disease with pathologic features of both neurodegenerative (aberrant TDP-43) and cerebrovascular (arteriolosclerosis) disease. As to potential therapeutic intervention, the human pharmacopeia features both SUR2 agonists and antagonists, so ABCC9/SUR2 may provide a "druggable target", relevant perhaps to both HS-Aging and Alzheimer's disease. We conclude that more work is required to better understand the roles of ABCC9/SUR2 in the human brain during health and disease conditions. |*Brain Diseases/drug therapy/metabolism/pathology[MESH] |*Cardiomegaly/genetics/metabolism/pathology[MESH] |*Hippocampus/metabolism/pathology[MESH] |*Hypertrichosis/genetics/metabolism/pathology[MESH] |*Osteochondrodysplasias/genetics/metabolism/pathology[MESH] |*Sulfonylurea Receptors/agonists/antagonists & inhibitors/genetics[MESH] |Aging/*physiology[MESH] |Animals[MESH] |Humans[MESH] |Mutation[MESH]ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of agi(epmc).pdf DeepDyve Pubget Overpricing