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10.4077/CJP.2015.BAD296 http://scihub22266oqcxt.onion/10.4077/CJP.2015.BAD296 26211648!ä!26211648 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chin+J+Physiol 2015 ; 58 (4): 244-53 Nephropedia Template TP {{tp|p=26211648|t=2015. Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1alpha via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line |pdf=|usr=}}{{26211648}} gab.com Text Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1alpha via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line JO: Chin J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26211648 #FOAvip Magnesium sulfate (MgSO(4)) ameliorates hypoxia/ischemia-induced neuronal apoptosis in a rat model. This study aimed to investigate the mechanisms governing the anti-apoptotic effect of MgSO(4) on cobalt chloride (CoCl(2))-exposed NB41A3 mouse neuroblastoma cells. MgSO(4) increased the viability of NB41A3 cells treated with CoCl(2) in a dose-dependent manner. MgSO(4) treatment was shown to lead to an increase in the anti-apoptotic Bcl-2 family proteins, with a concomitant decrease in the pro-apoptotic proteins. MgSO(4) also attenuated the CoCl(2)-induced disruption of mitochondrial membrane potential (DeltaPsi(m)) and reduced the release of cytochrome c form the mitochondria to the cytosol. Furthermore, exposure to CoCl(2) caused activation of the hypoxia-inducible factor 1alpha (HIF-1alpha). On the other hand, MgSO(4) markedly reduced CoCl(2)-induced HIF-1alpha activation and suppressed HIF-1alpha downstream protein BNIP3. MgSO(4) treatment induced ERK1/2 activation and attenuated CoCl(2)-induced activation of p38 and JNK. Addition of the ERK1/2 inhibitor U0126 significantly reduced the ability of MgSO(4) to protect neurons from CoCl(2)-induced mitochondrial apoptotic events. However, incubation of cultures with the p38 and JNK inhibitors did not significantly affect MgSO(4)-mediated neuroprotection. MgSO(4) appears to suppress CoCl(2)-induced NB41A3 cell death by activating ERK1/2/ MAPK pathways, which further modulates the role of Bcl-2 family proteins and mitochondria in NB41A3 cells. Our data suggest that MgSO(4) may act as a survival factor that preserves mitochondrial integrity and inhibits apoptotic pathways. Twit Text FOAVip Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1alpha via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line ????Chin J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26211648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26211648 #FOAvip English Wikipedia <ref>{{Cite pmid|26211648}}</ref> Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1alpha via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line #MMPMID26211648 Huang CY; Hsieh YL; Ju DT; Lin CC; Kuo CH; Liou YF; Ho TJ; Tsai CH; Tsai FJ; Lin JY Chin J Physiol 2015[Aug]; 58 (4): 244-53 PMID26211648show ga Magnesium sulfate (MgSO(4)) ameliorates hypoxia/ischemia-induced neuronal apoptosis in a rat model. This study aimed to investigate the mechanisms governing the anti-apoptotic effect of MgSO(4) on cobalt chloride (CoCl(2))-exposed NB41A3 mouse neuroblastoma cells. MgSO(4) increased the viability of NB41A3 cells treated with CoCl(2) in a dose-dependent manner. MgSO(4) treatment was shown to lead to an increase in the anti-apoptotic Bcl-2 family proteins, with a concomitant decrease in the pro-apoptotic proteins. MgSO(4) also attenuated the CoCl(2)-induced disruption of mitochondrial membrane potential (DeltaPsi(m)) and reduced the release of cytochrome c form the mitochondria to the cytosol. Furthermore, exposure to CoCl(2) caused activation of the hypoxia-inducible factor 1alpha (HIF-1alpha). On the other hand, MgSO(4) markedly reduced CoCl(2)-induced HIF-1alpha activation and suppressed HIF-1alpha downstream protein BNIP3. MgSO(4) treatment induced ERK1/2 activation and attenuated CoCl(2)-induced activation of p38 and JNK. Addition of the ERK1/2 inhibitor U0126 significantly reduced the ability of MgSO(4) to protect neurons from CoCl(2)-induced mitochondrial apoptotic events. However, incubation of cultures with the p38 and JNK inhibitors did not significantly affect MgSO(4)-mediated neuroprotection. MgSO(4) appears to suppress CoCl(2)-induced NB41A3 cell death by activating ERK1/2/ MAPK pathways, which further modulates the role of Bcl-2 family proteins and mitochondria in NB41A3 cells. Our data suggest that MgSO(4) may act as a survival factor that preserves mitochondrial integrity and inhibits apoptotic pathways. |Animals[MESH] |Apoptosis/*drug effects[MESH] |Cell Line, Tumor[MESH] |Cobalt/*pharmacology[MESH] |Extracellular Signal-Regulated MAP Kinases/*metabolism[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Membrane Potential, Mitochondrial/drug effects[MESH] |Mice[MESH] |Reactive Oxygen Species/metabolism[MESH]Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Acti(epmc).pdf DeepDyve Pubget Overpricing