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10.2215/CJN.00480115 http://scihub22266oqcxt.onion/10.2215/CJN.00480115 26100457!4491279!26100457     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26100457.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+J+Am+Soc+Nephrol 2015 ; 10 (7): 1128-35 Nephropedia Template TP {{tp|p=26100457|t=2015. Outcome and treatment of elderly patients with ANCA-associated vasculitis |pdf=|usr=}}{{26100457}} gab.com Text Outcome and treatment of elderly patients with ANCA-associated vasculitis JO: Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26100457 #FOAvip BACKGROUND AND OBJECTIVES: ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age >/=75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month. RESULTS: Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis. CONCLUSIONS: ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency. Twit Text FOAVip Outcome and treatment of elderly patients with ANCA-associated vasculitis ????Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26100457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26100457 #FOAvip English Wikipedia <ref>{{Cite pmid|26100457}}</ref> Outcome and treatment of elderly patients with ANCA-associated vasculitis #MMPMID26100457 Weiner M; Goh SM; Mohammad AJ; Hruskova Z; Tanna A; Bruchfeld A; Selga D; Chocova Z; Westman K; Eriksson P; Pusey CD; Tesar V; Salama AD; Segelmark M Clin J Am Soc Nephrol 2015[Jul]; 10 (7): 1128-35 PMID26100457show ga BACKGROUND AND OBJECTIVES: ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age >/=75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month. RESULTS: Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis. CONCLUSIONS: ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency. |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Comorbidity[MESH] |Disease Progression[MESH] |Europe[MESH] |Female[MESH] |Granulomatosis with Polyangiitis/complications/diagnosis/*drug therapy/mortality[MESH] |Humans[MESH] |Immunosuppressive Agents/*therapeutic use[MESH] |Kaplan-Meier Estimate[MESH] |Kidney Failure, Chronic/etiology[MESH] |Male[MESH] |Microscopic Polyangiitis/complications/diagnosis/*drug therapy/mortality[MESH] |Multivariate Analysis[MESH] |Proportional Hazards Models[MESH] |Renal Insufficiency/etiology[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |Severity of Illness Index[MESH] |Time Factors[MESH]Outcome and treatment of elderly patients with ANCA-associated vasculi(epmc).pdf DeepDyve Pubget Overpricing