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suck abstract from ncbi


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pmid2609140      Schweiz+Med+Wochenschr 1989 ; 119 (50): 1837-9
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  • Wirkung von Trichlormethiazid und Amilorid auf die zellulare Na+-, K+- und Mg2+-Konzentration #MMPMID2609140
  • Kisters K; Zidek W; Rahn KH
  • Schweiz Med Wochenschr 1989[Dec]; 119 (50): 1837-9 PMID2609140show ga
  • While diuretic-induced changes of plasma electrolyte concentrations have often been described, comparatively few data exist on intracellular electrolyte concentrations under diuretic treatment. Therefore, we studied the effect on intracellular Mg2+, Na+ and K+ concentrations of a thiazide diuretic (trichlormethiazide 4 mg/d) in red blood cells of 14 patients with mild essential hypertension, and of a combination of a thiazide diuretic and a potassium-sparing diuretic (trichlormethiazide and amiloride 2 mg/d each) in red blood cells of 11 patients with mild essential hypertension. Measurements were performed by atomic absorption spectroscopy and flame photometry before starting treatment and after 4 and 8-12 weeks' diuretic treatment. There was no significant change in intracellular Na+ and K+ concentrations under either form of diuretic treatment. Intracellular Mg2+ concentrations decreased significantly under thiazide therapy, whereas there was a significant increase in intracellular Mg+ concentrations under thiazide and potassium-sparing combined diuretic therapy. The results show that the combination of a thiazide diuretic and a potassium-sparing diuretic is a useful means to avoid intracellular Mg2+ loss.
  • |Amiloride/*pharmacology[MESH]
  • |Drug Combinations[MESH]
  • |Electrolytes/*blood[MESH]
  • |Erythrocytes/*analysis[MESH]
  • |Humans[MESH]
  • |Magnesium/blood[MESH]
  • |Potassium/blood[MESH]
  • |Sodium/blood[MESH]
  • |Spectrophotometry, Atomic[MESH]


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