Intravenose Magnesium-Gabe bei Asthma bronchiale #MMPMID2609133
Hauser SP; Braun PH
Schweiz Med Wochenschr 1989[Nov]; 119 (46): 1633-5 PMID2609133show ga
The effect of intravenously infused Mg-aspartate hydrochloride (MgAHCl) was studied in 17 asthmatic inpatients. In 6 patients with initial forced vital capacity (FVC) greater than 90% of normal value, there were no significant changes in the lung volumina after 10 mmol of MgAHCl. In 11 patients with initial FVC less than or equal to 90%, the median FVC increased after MgAHCl by 56 to 61% (p less than 0.01), the forced expiratory volume at 1 sec. (FEV1) by 40 to 44% (p less than 0.02) and the peak expiratory flow (PEF) by 45 to 56% (p less than 0.02). No significant changes of respiratory resistance were observed. The average serum concentration of Mg increased by 0.89 to 1.72 mmol/L and decreased to 1.33 mmol/L 20 minutes after the Mg-infusion. Intravenous infusion of Mg produces a significant improvement of FVC, FEV1 and PEF. With its cardioprotective effect and the reduction of bronchial hyperreactivity, Mg could be a valuable method in the treatment of asthmatic patients.
Schweiz+Med+Wochenschr 1989 ; 119 (46): 1633-5
