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10.1371/journal.ppat.1004871 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1004871 26086192!4472755!26086192     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2015 ; 11 (6): e1004871 Nephropedia Template TP {{tp|p=26086192|t=2015. Targeting Human Transmission Biology for Malaria Elimination |pdf=|usr=}}{{26086192}} gab.com Text Targeting Human Transmission Biology for Malaria Elimination JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26086192 #FOAvip Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by many endemic countries to eliminate malaria marks a shift away from programs aimed at controlling disease burden towards one that emphasizes reducing transmission of the most virulent human malaria parasite, Plasmodium falciparum. Gametocytes, the only developmental stage of malaria parasites able to infect mosquitoes, have remained understudied, as they occur in low numbers, do not cause disease, and are difficult to detect in vivo by conventional methods. Here, we review the transmission biology of P. falciparum gametocytes, featuring important recent discoveries of genes affecting parasite commitment to gametocyte formation, microvesicles enabling parasites to communicate with each other, and the anatomical site where immature gametocytes develop. We propose potential parasite targets for future intervention and highlight remaining knowledge gaps. Twit Text FOAVip Targeting Human Transmission Biology for Malaria Elimination ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26086192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26086192 #FOAvip English Wikipedia <ref>{{Cite pmid|26086192}}</ref> Targeting Human Transmission Biology for Malaria Elimination #MMPMID26086192 Nilsson SK; Childs LM; Buckee C; Marti M PLoS Pathog 2015[Jun]; 11 (6): e1004871 PMID26086192show ga Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by many endemic countries to eliminate malaria marks a shift away from programs aimed at controlling disease burden towards one that emphasizes reducing transmission of the most virulent human malaria parasite, Plasmodium falciparum. Gametocytes, the only developmental stage of malaria parasites able to infect mosquitoes, have remained understudied, as they occur in low numbers, do not cause disease, and are difficult to detect in vivo by conventional methods. Here, we review the transmission biology of P. falciparum gametocytes, featuring important recent discoveries of genes affecting parasite commitment to gametocyte formation, microvesicles enabling parasites to communicate with each other, and the anatomical site where immature gametocytes develop. We propose potential parasite targets for future intervention and highlight remaining knowledge gaps. |Animals[MESH] |Culicidae/*parasitology[MESH] |Humans[MESH] |Life Cycle Stages[MESH] |Malaria, Falciparum/*transmission[MESH]Targeting Human Transmission Biology for Malaria Elimination (epmc).pdf DeepDyve Pubget Overpricing