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10.1371/journal.pone.0128437 http://scihub22266oqcxt.onion/10.1371/journal.pone.0128437 26039496!4454579!26039496     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26039496&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2015 ; 10 (6): e0128437 Nephropedia Template TP {{tp|p=26039496|t=2015. Detecting minimal hepatic encephalopathy in an endemic country for hepatitis B: the role of psychometrics and serum IL-6 |pdf=|usr=}}{{26039496}} gab.com Text Detecting minimal hepatic encephalopathy in an endemic country for hepatitis B: the role of psychometrics and serum IL-6 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26039496 #FOAvip BACKGROUND & AIMS: It remains unknown what the prevalence of minimal hepatic encephalopathy is in Taiwan, a highly endemic country for chronic viral hepatitis infection. It is also unclear whether abnormal serum cytokine levels can be indicative of the presence of minimal hepatic encephalopathy. We aimed to standardize the tests of psychometric hepatic encephalopathy score and predictive value of proinflammatory cytokines in minimal hepatic encephalopathy in Taiwan. METHODS: 180 healthy subjects and 94 cirrhotic patients without a history of overt hepatic encephalopathy from a tertiary center were invited to participate in this cross-sectional study. Blood sampling for determination of serum levels of interleukin 6 and 18 and tumor necrosis factor-alpha was performed. Based on the normogram of psychometric hepatic encephalopathy score from healthy volunteers, patients with minimal hepatic encephalopathy were identified from the cirrhotic patients using the criterion of a psychometric hepatic encephalopathy score less than -4. RESULTS: In the healthy subjects, age and education were predictors of subtests of psychometric hepatic encephalopathy score. Minimal hepatic encephalopathy was identified in 27 (29%) cirrhotic patients. Serum interleukin 6 level (OR = 6.50, 95% CI = 1.64-25.76, P = 0.008) was predictive of the presence of minimal hepatic encephalopathy after multivariate analysis. CONCLUSIONS: The psychometric hepatic encephalopathy score can be a useful tool for detecting patients with minimal hepatic encephalopathy in Taiwan and around one third of cirrhotic outpatients fulfill this diagnosis. A high serum interleukin 6 level is predictive of the presence of minimal hepatic encephalopathy. Twit Text FOAVip Detecting minimal hepatic encephalopathy in an endemic country for hepatitis B: the role of psychometrics and serum IL-6 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26039496 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039496 #FOAvip English Wikipedia <ref>{{Cite pmid|26039496}}</ref> Detecting minimal hepatic encephalopathy in an endemic country for hepatitis B: the role of psychometrics and serum IL-6 #MMPMID26039496 Tsai CF; Chu CJ; Huang YH; Wang YP; Liu PY; Lin HC; Lee FY; Lu CL PLoS One 2015[]; 10 (6): e0128437 PMID26039496show ga BACKGROUND & AIMS: It remains unknown what the prevalence of minimal hepatic encephalopathy is in Taiwan, a highly endemic country for chronic viral hepatitis infection. It is also unclear whether abnormal serum cytokine levels can be indicative of the presence of minimal hepatic encephalopathy. We aimed to standardize the tests of psychometric hepatic encephalopathy score and predictive value of proinflammatory cytokines in minimal hepatic encephalopathy in Taiwan. METHODS: 180 healthy subjects and 94 cirrhotic patients without a history of overt hepatic encephalopathy from a tertiary center were invited to participate in this cross-sectional study. Blood sampling for determination of serum levels of interleukin 6 and 18 and tumor necrosis factor-alpha was performed. Based on the normogram of psychometric hepatic encephalopathy score from healthy volunteers, patients with minimal hepatic encephalopathy were identified from the cirrhotic patients using the criterion of a psychometric hepatic encephalopathy score less than -4. RESULTS: In the healthy subjects, age and education were predictors of subtests of psychometric hepatic encephalopathy score. Minimal hepatic encephalopathy was identified in 27 (29%) cirrhotic patients. Serum interleukin 6 level (OR = 6.50, 95% CI = 1.64-25.76, P = 0.008) was predictive of the presence of minimal hepatic encephalopathy after multivariate analysis. CONCLUSIONS: The psychometric hepatic encephalopathy score can be a useful tool for detecting patients with minimal hepatic encephalopathy in Taiwan and around one third of cirrhotic outpatients fulfill this diagnosis. A high serum interleukin 6 level is predictive of the presence of minimal hepatic encephalopathy. |*Endemic Diseases[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |Case-Control Studies[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Hepatic Encephalopathy/blood/*diagnosis/epidemiology/psychology[MESH] |Hepatitis B, Chronic/blood/*diagnosis/epidemiology/psychology[MESH] |Humans[MESH] |Interleukin-18/blood[MESH] |Interleukin-6/*blood[MESH] |Liver Cirrhosis/blood/*diagnosis/epidemiology/psychology[MESH] |Male[MESH] |Middle Aged[MESH] |Multivariate Analysis[MESH] |Neuropsychological Tests[MESH] |Predictive Value of Tests[MESH] |Severity of Illness Index[MESH] |Taiwan/epidemiology[MESH]Detecting minimal hepatic encephalopathy in an endemic country for hep(epmc).pdf DeepDyve Pubget Overpricing